AI Article Synopsis
- The study developed a novel bioactive coating using chitosan (Chi) and anionic surfactant (77KS) for drug delivery of amoxicillin (AMOX) on a PDMS surface.
- The interaction between Chi and 77KS was analyzed using turbidity and ζ-potential measurements, while the stability and adsorption of the coating were assessed with quartz crystal microbalance (QCM-D).
- Results indicated stable adsorption of the coating on non-activated PDMS, but it desorbed from UVO-activated PDMS after rinsing, confirmed by X-ray and mass spectrometry analysis.
Article Abstract
Chitosan (Chi) and anionic surfactant derived from lysine (77KS) were used to prepare a novel bioactive coating and as a drug delivery system for amoxicillin (AMOX) on a model polydimethylsiloxane (PDMS) surface. The bioactive coating was formulated as polyelectrolyte-surfactant complex (PESC). Aggregation behaviour between the cationic Chi and oppositely charged 77KS in bulk was analysed using turbidity and ζ-potential measurement. Furthermore, the adsorption and stability of the formulations were evaluated using quartz crystal microbalance with dissipation (QCM-D). The effect of the ionic strength and of the ultraviolet/ozone (UVO) activation of the PDMS films on the adsorption behaviour of the PESC complex was also examined. QCM-D monitoring showed stable adsorption of bare and AMOX-loaded complex on non-activated PDMS films, while the coating on UVO-activated PDMS samples desorbed after the rinsing step. Finally, X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry confirmed successful and homogenously distributed compounds.
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| http://dx.doi.org/10.1016/j.carbpol.2019.115817 | DOI Listing |
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