Alzheimer's Disease (AD) is a devastating neurodegenerative disorder currently affecting 45 million people worldwide, ranking as the 6th highest cause of death. Throughout the development and progression of AD, over 90% of patients display behavioral and psychological symptoms of dementia (BPSD), with some of these symptoms occurring before memory deficits and therefore serving as potential early predictors of AD-related cognitive decline. However, the biochemical links between AD and BPSD are not known. In this study, we explored the molecular interactions between AD and BPSD using protein-protein interaction (PPI) networks built from OMIM (Online Mendelian Inheritance in Man) genes that were related to AD and two distinct BPSD domains, the Affective Domain and the Hyperactivity, Impulsivity, Disinhibition, and Aggression (HIDA) Domain. Our results yielded 8 unique proteins for the Affective Domain (RHOA, GRB2, PIK3R1, HSPA4, HSP90AA1, GSK3beta, PRKCZ, and FYN), 5 unique proteins for the HIDA Domain (LRP1, EGFR, YWHAB, SUMO1, and EGR1), and 6 shared proteins between both BPSD domains (APP, UBC, ELAV1, YWHAZ, YWHAE, and SRC) and AD. These proteins might suggest specific targets and pathways that are involved in the pathogenesis of these BPSD domains in AD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968845 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0226021 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
A Framework for Behavioral Health Integration in the Program of All-Inclusive Care for the Elderly (PACE).
J Am Geriatr Soc
January 2025
New York State Psychiatric Institute, New York, New York, USA.
Background: The Program of All-inclusive Care for the Elderly (PACE) is a comprehensive care model that aims to promote aging in the home and community for older adults who are nursing-home eligible needs-wise. Older adults experience age-related barriers to accessing behavioral health (BH) services. PACE programs play an important role in providing all-inclusive health care for individuals over 55 who are dually eligible for Medicaid and Medicare.
View Article and Find Full Text PDFElevated plasma total homocysteine levels are associated with behavioral and psychological symptoms in dementia with Lewy bodies.
Front Neurosci
November 2024
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- This study aimed to explore the link between plasma total homocysteine (tHcy) levels and behavioral and psychological symptoms of dementia (BPSD) in patients with dementia with Lewy bodies (DLB).
- Among 82 DLB patients, a significant 92.7% exhibited clinically significant BPSD, with hallucinations and apathy being the most common symptoms; elevated tHcy levels were notably associated with higher NPI scores in DLB patients.
- The findings suggest that controlling homocysteine levels might provide a new approach for managing BPSD in DLB, although further research with larger groups is needed to confirm these results.
Association of Neuropsychiatric Inventory Questionnaire Score With Caregiver Relationship in Alzheimer's Disease Dementia and Mild Cognitive Impairment.
J Appl Gerontol
December 2024
Department of Occupational Therapy, Kyoto Tachibana University, Kyoto, Japan.
Article Synopsis
- - The study investigated the behavioral and psychological symptoms of dementia (BPSD) in patients with Alzheimer’s disease dementia (ADD) and mild cognitive impairment (MCI), focusing on how caregiver relationships affect these symptoms.
- - Researchers evaluated cognitive function in 419 patients using two tests and found significant connections between caregiver relationships and factors like patient age, education level, and total BPSD scores based on the Neuropsychiatric Inventory Questionnaire (NPI-Q).
- - Specific symptoms such as delusions and irritability were notably tied to the caregiver’s relationship with the patient, with female caregivers reporting higher scores in certain emotional symptoms, indicating that the caregiver’s role can influence the patient’s psychological state.
Shoulder Joint Range of Motion Related to Dementia.
Dement Geriatr Cogn Disord
August 2024
Department of Occupational Therapy, Faculty of Health Science, Kyoto Tachibana University, Kyoto, Japan.
Introduction: Dementia is caused by various diseases, including Alzheimer's disease dementia (ADD) and dementia with Lewy bodies (DLB). We often encounter patients with dementia who have limited shoulder joint range of motion (ROM), especially those with behavioral and psychological symptoms of dementia (BPSD). But the relationship between the diseases of dementia and restricted shoulder joint ROM is currently unclear.
View Article and Find Full Text PDFBPSDiary study protocol: a multi-center randomized controlled trial to compare the efficacy of a BPSD diary vs. standard care in reducing caregiver's burden.
Front Dement
December 2023
Neurology Department, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Unlabelled: Behavioral and Psychological Symptoms of Dementia (BPSD) are a heterogeneous set of psychological and behavioral abnormalities seen in persons with dementia (PwD), significantly impacting their quality of life and that of their caregivers. Current assessment tools, such as the Neuropsychiatric Inventory (NPI), are limited by recall bias and lack of direct observation. This study aims to overcome this limitation by making caregiver reports more objective through the use of a novel instrument, referred to as the BPSDiary.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!