As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2019) have created novel fluorescence-based linkers to quantify the rate of intracellular bond cleavage and track live-cell kinetics for designing more effective agents.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297053 | PMC |
| http://dx.doi.org/10.1016/j.chembiol.2019.12.001 | DOI Listing |
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