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Mutations and Overexpression of Associated with DMI-Resistance in from Chili. | LitMetric

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Article Abstract

Chili anthracnose caused by spp. is an annual production concern for growers in China. Sterol C14-demethylation inhibitors (DMIs, such as tebuconazole) have been widely used to control this disease for more than three decades. In the current study, of 48 isolates collected from commercial chili farms in Jiangsu Province of China during 2018 and 2019, 8 single-spore isolates were identified as and the rest were identified as . To determine whether the DMI resistance of isolates develops in the field, mycelial growth of the 48 isolates was measured in culture medium with and without tebuconazole. In all, 6 of the 8 isolates were resistant to tebuconazole, but all 40 of the isolates were sensitive to tebuconazole. The fitness cost of resistance was low based on a comparison of fitness parameters between the sensitive and resistant isolates of Positive cross-resistance was observed between tebuconazole and difenconazole or propiconazole, but not prochloraz. Alignment results of the CgCYP51 amino acid sequences from the sensitive and resistant isolates indicated that mutations can be divided into three genotypes. Genotype I possessed four substitutions (V18F, L58V, S175P, and P341A) at the gene but no substitutions at , while genotype II had five substitutions (L58V, S175P, A340S, T379A, and N476T) at , concomitant with three substitutions (D121N, T132A, and F391Y) at . In addition, genotype III contained two substitutions (L58V and S175P) at , concomitant with one substitution (T262A) at . Molecular docking models illustrated that the affinity of tebuconazole to the binding site of the CgCYP51 protein from the resistant isolates was decreased when compared with binding site affinity of the sensitive isolates. Our findings provide not only novel insights into understanding the resistance mechanism to DMIs, but also some important references for resistance management of on chili.

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http://dx.doi.org/10.1094/PDIS-08-19-1628-REDOI Listing

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