Objectives: To evaluate the effect of silodosin on stages of the flexible ureterorenoscopy (F-URS) procedures.
Methods: Between November 2015 and August 2017, a total of 76 patients suffering from 10-30 mm kidney stone were enrolled in this randomized prospective study. Patients were randomly divided into 2 groups for treatment: Group 1 had F-URS with preoperative daily uptake of 8 mg silodosin for 10 days, and group 2 had F-URS without silodosin uptake. None of the patients had preoperative JJ stenting. Stages of the F-URS was defined as entrance to bladder time (ETBT) with a semirigid ureterorenoscope (R-URS), entrance to ureteric orifice time (ETUOT) with R-URS using a guide wire and proceeding 2 cm inside the ureter, application of access sheath time (AAST) using the guide wire advanced through R-URS, F-URS time (FURST) + lithotripsy with laser time (LT), and total operation time (OT). We compared the time of each stage between two groups.
Results: There were 38 patients group1 and 2, respectively. There was one ureteral access sheath (UAS) application failure in group 1, and 3 failures in group 2 (p=0.307). The ETBT, ETUOT, and AAST were significantly short in group 1 than group 2 (p=0.001,0.007,0.002).
Conclusions: Although preoperative use of silodosin facilitated only an insignificant positive effect on UAS placement failure, it eased the F-URS procedure by reducing the ETBT, ETUOT, and AAST in seconds. More studies are needed to make an exact conclusion.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Does Silodosin Improve Primary Ureteroscopy Access and Outcomes: Meta-Analysis of Randomized Controlled Trials.
J Endourol
November 2024
Department of Urology, Royal London Hospital, London, United Kingdom.
Ureteroscopy (URS) is a widely utilized procedure for the management of urinary stones, though failed access due to ureteral orifice tightness or spasms can be a potential outcome. Silodosin, an alpha-1A adrenergic receptor antagonist, has shown promise in recent randomized controlled trials (RCTs) in improving URS outcomes by relaxing ureteral smooth muscle. This systematic review and meta-analysis aims to determine whether preoperative administration of silodosin enhances ureteroscopy outcomes, including ureteral access rates, operative time, complication rates, and stone-free rates.
View Article and Find Full Text PDFEffect of preoperative alpha-blockers on ureteroscopy outcomes: A meta-analysis of randomised trials.
BJUI Compass
July 2024
Department of Biostatistics Miller Scientific Johnson City Tennessee USA.
Article Synopsis
- This study evaluates how effective and safe preoperative alpha-blocker therapy is for patients undergoing ureteroscopy (URS) for kidney stones.
- It includes a systematic review of 15 randomized trials with over 1600 patients, showing that adding alpha-blockers significantly reduces complications, procedure time, and stone retention rates.
- However, while beneficial, alpha-blockers increase the risk of ejaculatory dysfunction and are less effective for stones in the renal/proximal ureter area.
Preoperative α1-Blockers Impact on Outcomes of Patients Undergoing Ureteroscopy with Ureteral Access Sheaths: A Systematic Review and Meta-Analysis.
J Endourol
September 2024
Department of Surgery, Universidade Federal de Pernambuco, Recife, Brazil.
The use of a ureteral access sheath (UAS) during ureteroscopy (URS) has been associated with the risk for ureteral injuries. Preoperative administration of α1-blockers presents a potential mitigator of such lesions by inducing ureteral relaxation, which may also contribute to improving other surgical outcomes. A comprehensive literature search was conducted across MEDLINE, Embase, and Cochrane databases for studies comparing preoperative α1-blockers administration its non-use in adult patients without pre-stenting undergoing URS.
View Article and Find Full Text PDFEfficacy of pre-operative silodosin on flexible ureteroscopy procedure: A randomized controlled study.
Arab J Urol
May 2023
Urology Department, Faculty of Medicine, Benha University, Benha, Egypt.
Objectives: To evaluate the impact of silodosin on stages of flexible ureteroscopy (F-URS) procedures, complications, and stone-free rate (SFR).
Patients And Methods: A prospective, randomized, controlled comparison research was conducted on 106 patients who were randomly allocated into two groups: the study group (52 patients) received F-URS with preoperative daily uptake of 8 mg silodosin for 10 days, and the control group (54 patients) received F- URS without silodosin uptake. Two patients were lost during the follow up in the study group and four patients were also lost in the controls.
Does preoperative silodosin administration facilitate ureteral dilatation during flexible ureterorenoscopy? A randomized clinical trial.
Int Urol Nephrol
March 2024
Urology Department, Faculty of Medicine, Benha University, Benha, Qalyubiyya Governorate, Egypt.
Purpose: To assess whether preoperative administration of silodosin can facilitate the placement of ureteral access sheath (UAS) prior to flexible ureteroscopy (F-URS) and reduce the occurrence of ureteric injury in challenging cases.
Methods: This prospective randomized clinical trial was carried out on 147 patients diagnosed with upper ureteric stone or stone kidney, non-stented. The patients were randomly divided into two equal groups.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!