AI Article Synopsis
- A pathogenic bacterium that causes bovine mastitis is a serious concern in the dairy industry, especially with the rise of multi-drug resistant strains.
- Researchers previously isolated a strain that produces a bacteriocin with strong antimicrobial effects against this bacterium.
- This study found that using a combination of the bacteriocin and a specific bacteriophage (SAP84) significantly enhanced the inhibition of the pathogen's growth, suggesting that their combined use could effectively control harmful bacteria in dairy contexts.
Article Abstract
is a representative pathogenic bacterium carefully controlled in the dairy industry because it causes bovine mastitis and thus, can enter the dairy chain. Furthermore, the emergence of multi-drug resistant is a big problem. We previously isolated a strain producing a bacteriocin that exhibited strong antimicrobial activity against . In this study, we investigated the synergistic inhibition of by the bacteriocin and a bacteriophage (SAP84) which is specific to the organism. The bacteriocin (12.5-100 AU/mL) inhibited the growth of KCTC 3881 in a dose-dependent manner, as did the bacteriophage SAP84 (0.001-1 MOI; multiplicity of infection). Co-treatment with the bacteriocin (100 AU/mL) and the bacteriophage (0.1 MOI) significantly inhibited the growth of compared to each treatment alone (bacteriocin or bacteriophage), indicating the two components showed synergistic inhibition of . Therefore, the bacteriocin and bacteriophage combination can be used as a good strategy for controlling pathogenic bacteria.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949521 | PMC |
| http://dx.doi.org/10.5851/kosfa.2019.e95 | DOI Listing |
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