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Association of GCKR rs780094 polymorphism with circulating lipid levels in type 2 diabetes and hyperuricemia in Uygur Chinese. | LitMetric

AI Article Synopsis

  • The study explored the connection between the GCKR rs780094 genetic variant and lipid profiles in the Xinjiang Uygur population, focusing on 980 type 2 diabetes (T2DM) patients, 1017 hyperuricemia (HUA) patients, and 1185 healthy controls.
  • Findings revealed that T2DM participants had higher total cholesterol (TC) and lower HDL cholesterol levels compared to controls, while HUA subjects exhibited elevated triglycerides (TG) and reduced HDL cholesterol levels.
  • The rs780094 variant was linked to increased HUA risk, especially in males, and interactions between genetic variants and lipid levels highlighted the significance of gender in influencing lipid profiles among these populations.

Article Abstract

To investigate the relationship between a GCKR rs780094 polymorphism and lipid profiles in the Xinjiang Uygur population in China. 980 type 2 diabetes mellitus (T2DM) patients, 1017 hyperuricemia (HUA) and 1185 healthy controls were included in this study. After genotyping of rs780094 by Sequenom Mass ARRAY system, chi-square test and logistic regression analysis were used for association analysis as well as a genotype-phenotype analysis. We found that the serum concentration of TC (P<0.001) was significantly higher and HDL-C (P<0.001) was lower in T2DM than in control participants. Subjects with HUA had a significantly higher TG (P=0.003) and lower HDL-C (P<0.001) than control participants. Additionally, under the recessive model, rs780094 was shown to be associated with the risk of HUA (P=0.015, OR=1.311), particularly in males (P=0.047, OR=1.330). Subsequent interaction analysis between rs780094 and lipid parameters showed that the TG level was positively correlated with HUA in the rs780094- AA+AG carriers (P=0.005). The TC concentrations showed to be associated with T2DM in the rs780094- AA+AG carriers (P<0.001). The association between lipid parameters and gender showed that significantly higher TG levels (P<0.001) and lower HDL-C levels (P<0.001) were observed in female HUA. Higher LDL-C levels were found in male HUA (P=0.015). Moreover, statistically higher TC levels and lower HDL-C levels were found both in male and female T2DM cases (TC: male: P<0.001, female: P=0.014. HDL-C: male: P<0.001, female: P<0.001.).To conclude, our results demonstrated that different genotypes of rs780094 had different effects on blood lipids in HUA and T2DM patients in a Uygur population. Gender was also one of the factors influencing blood lipid levels.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962982PMC

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