Testicular germ cell tumors: a clinicopathological and immunohistochemical analysis of 145 cases.

Testicular germ cell tumor (TGCT) is the most common tumor usually occuring in males between 20-40 years old. In recentyears, the incidence of TGCTs has risen markedly. The outcome depends on its pathologic type and tumor stage. This study was a retrospective analysis of the clinicopathological and immunohistochemical of 145 TGCTs. According to our findings, teratoma, both mature and immature, mostly involved children, as did yolk sac tumor. Patients under 18 years old all survived for at least five years, while the mortality rate was 87.8% after five years since surgery and 96.5% in adults after three years. There was no difference between the survival rate of seminomatous tumor and non-seminomatous tumor. We also analyzed two routine diagnostic markers-PLAP and OCT4 on all TGCT tissues. Results showed that OCT4 may be a better predictive marker than PLAP to distinguish the TGCTS. Our finding suggested that TGCTs mostly occurred in young adult, and the mortality of those who under 18 years old is lower than the adult patients. However in distinguishing the seminoma tumor from non-seminoma tumor, new marker should be further study.