Malakoplakia is a rare granulomatous inflammatory condition, which is usually mistaken as malignant because prostatic malakoplakia can cause the formation of a prostatic mass and thickening of the bladder wall. The diagnosis of malakoplakia requires a histopathologic examination and is strongly supported by the presence of Michaelis-Gutmann bodies. It has been reported that malakoplakia of the prostate (prostatic malakoplakia) may be accompanied by a tumor. We report a case of malakoplakia which was initially diagnosed as prostate carcinoma but revised based on a perineal biopsy. We did not find prostate carcinoma with a 4 year follow-up.
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Department of Pathology, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, Sichuan, China.
Prostatic malakoplakia is an uncommon chronic inflammatory disorder, tumor-like but non-cancerous, the diagnosis of which pivots crucially on the identification of characteristic Michaelis-Gutmann bodies within the pathological tissue. We hereby present an inaugural case report of prostatic malakoplakia concurrent with sepsis caused by multidrug-resistant Escherichia coli, verified through blood culture and metagenomic next-generation sequencing (mNGS). The pathogenesis might be associated with infections by Escherichia coli, immune system irregularities, or lysosomal dysfunction.
View Article and Find Full Text PDFMultiparameter MRI features of prostatic malakoplakia.
Br J Radiol
January 2025
Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Article Synopsis
- This study examined the imaging features of prostatic malakoplakia in 11 patients, all confirmed through pathology, with a median age of 62 years.
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Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, China. Electronic address:
Case report: Prostatic malakoplakia: a rare disease that has a profile mimicking prostate cancer.
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Department of Medical Ultrasound, West China Hospital, Sichuan University, Chengdu, China.
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