AI Article Synopsis
Article Abstract
Somatic mutation profiling in gastric cancer (GC) enables main driver mutations to be identified and their clinical and prognostic value to be evaluated. We investigated 77 tumour samples of GC by next-generation sequencing (NGS) with the Ion AmpliSeq Hotspot Panel v2 and a custom panel covering six hereditary gastric cancer predisposition genes (BMPR1A, SMAD4, CDH1, TP53, STK11 and PTEN). Overall, 47 somatic mutations in 14 genes were detected; 22 of these mutations were novel. Mutations were detected most frequently in the CDH1 (13/47) and TP53 (12/47) genes. As expected, somatic CDH1 mutations were positively correlated with distant metastases (p = 0.019) and tumours with signet ring cells (p = 0.043). These findings confirm the association of the CDH1 mutations with diffuse GC type. TP53 mutations were found to be significantly associated with a decrease in overall survival in patients with Lauren diffuse-type tumours (p = 0.0085), T3-T4 tumours (p = 0.037), and stage III-IV tumours (p = 0.013). Our results confirm that the detection of mutations in the main driver genes may have a significant prognostic value for GC patients and provide an independent GC-related set of clinical and molecular genetic data.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965114 | PMC |
| http://dx.doi.org/10.1038/s41598-020-57544-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
'Making abortion safe': abortion and post-abortion care providers' experiences of stigma in Rwanda, Zimbabwe, Sierra Leone and Nigeria.
BMJ Sex Reprod Health
December 2024
Faculty of Health and Social Care, The Open University, Milton Keynes, UK
Background: Social stigma and the marginalisation of abortion care within medical settings can negatively affect abortion providers. While some research has evaluated stigma interventions in legally restrictive settings, little work has explored the experiences of healthcare professionals (HCPs) providing abortion and post-abortion care (PAC) outside the USA. This study, part of the Royal College of Obstetricians and Gynaecologists' 'Making Abortion Safe' programme, aimed to understand providers' experiences of abortion stigma in four African countries with restrictive legislation.
View Article and Find Full Text PDF[Quantitative Analysis of the Drivers of the Spatio-temporal Evolution of Vegetation NPP in the Beijing-Tianjin-Hebei Ecological Barrier Area].
Huan Jing Ke Xue
January 2025
College of Land and Resources, Hebei Agricultural University, Baoding 071001, China.
The Taihangshan-Yanshan Region is an important ecological barrier area in Beijing-Tianjin-Hebei, and it is of great importance to investigate the spatial distribution pattern and driving mechanism of net primary productivity （NPP） of vegetation for ecological restoration. The MOD17A3HGF.061 NPP dataset was obtained using the Google earth engine（GEE）, and Sen trend, coefficient of variation, partial correlation, complex correlation, and residual analysis were applied to investigate the spatial and temporal patterns of vegetation NPP in the study area and to quantitatively isolate the relative contributions of climate change and human activities.
View Article and Find Full Text PDFRegionally differentiated responses of chlorophyll-a concentrations to reduced human activity during COVID-19 lockdown in the San Francisco Bay area.
J Environ Manage
December 2024
College of Oceanography and Ecological Science, Shanghai Ocean University, Shanghai, 201306, China.
The COVID-19 lockdown created a unique opportunity to study the impact of reduced human activities on water quality. This study aimed to explore how changes in human activities, specifically reduced traffic emissions, influenced water quality in the San Francisco Bay Area from 2019 to 2021. Using chlorophyll-a (Chl-a) concentration as an indicator of water quality and NO₂ concentration as a proxy for traffic emissions, we analyzed the effects of reduced emissions on water quality across different regions of the Bay.
View Article and Find Full Text PDFBehaviours and drivers of diagnosis-related group upcoding in China: A mixed-methods study.
Soc Sci Med
December 2024
Department of Health Policy and Management, School of Public Health, Peking University, Beijing, China. Electronic address:
As a highly destructive gaming behaviour in Diagnosis-Related Group (DRG), upcoding has garnered increasing scholarly attention. This study considers the prevalence, types and risk characteristics of upcoding during the pilot implementation of DRG payments in China, and it also explores the drivers of upcoding and provides corresponding policy recommendations for improving the system. Quantitative research data were sourced from the DRG payment audit database in City Z between the dates of June 1, 2019 and May 31, 2020, encompassing audit results comprising 200 medical records randomly selected from 28 hospitals.
View Article and Find Full Text PDFSex Differences in Basal Cortisol Levels Across Body Fluid Compartments in a Cross-sectional Study of Healthy Adults.
J Endocr Soc
November 2024
VA Northwest Mental Illness Research, Education and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Context: Many studies have moved toward saliva and peripheral blood sampling for studying cortisol, even in relation to disorders of the brain. However, the degree to which peripheral cortisol reflects central cortisol levels has yet to be comprehensively described. Data describing the effect that biological characteristics such as age and sex have on cortisol levels across compartments is also limited.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!