Metabolic reprogramming in macrophages supports effector functions and differs depending on the activating stimulus. Lauterbach et al. now show that early metabolic alterations in macrophages driven by LPS signaling serve to increase the acetyl-CoA pool via citrate metabolism by the ATP-citrate lyase (ACLY), leading to histone acetylation and regulation of TLR-driven gene expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.it.2019.12.009 | DOI Listing |
Publication Analysis
Top Keywords
acly-matizing macrophages
4
macrophages histone
4
histone modification
4
modification immunometabolic
4
immunometabolic reprogramming
4
reprogramming metabolic
4
metabolic reprogramming
4
reprogramming macrophages
4
macrophages supports
4
supports effector
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!