AI Article Synopsis
- The study aimed to identify risk factors for cow's milk protein allergy (CMPA) in infants through a multicenter clinical approach involving 1,829 infants.
- Risk factors found include maternal food allergy, antibiotic exposure during pregnancy, and introducing complementary foods before 4 months; protective factors include exclusive breastfeeding and introducing complementary foods after 6 months.
- The research highlights the importance of timing and maternal health in reducing the risk of CMPA in infants.
Article Abstract
Objective: To investigate the risk factors for cow's milk protein allergy (CMPA) among infants through a multicenter clinical study.
Methods: A total of 1 829 infants, aged 1-12 months, who attended the outpatient service of the pediatric department in six hospitals in Shenzhen, China from June 2016 to May 2017 were enrolled as subjects. A questionnaire survey was performed to screen out suspected cases of CMPA. Food avoidance and oral food challenge tests were used to make a confirmed diagnosis of CMPA CMPA. A multivariate logistic regression analysis was used to investigate the risk factors for CMPA.
Results: Among the 1 829 infants, 82 (4.48%) were diagnosed with CMPA. The multivariate logistic regression analysis showed that maternal food allergy (OR=4.91, 95%CI: 2.24-10.76, P<0.05), antibiotic exposure during pregnancy (OR=3.18, 95%CI: 1.32-7.65, P<0.05), and the introduction of complementary food at an age of <4 months (OR=3.55, 95%CI: 1.52-8.27, P<0.05) were risk factors for CMPA, while exclusive breastfeeding (OR=0.21, 95%CI: 0.08-0.58, P<0.05) and the introduction of complementary food at an age of >6 months (OR=0.38, 95%CI: 0.17-0.86, P<0.05) were protective factors.
Conclusions: The introduction of complementary food at an age of <4 months, maternal food allergy, and antibiotic exposure during pregnancy are risk factors for CMPA in infants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7389720 | PMC |
| http://dx.doi.org/10.7499/j.issn.1008-8830.2020.01.009 | DOI Listing |
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