Purpose: To perform concurrent TMS-fMRI on difficult targets, such as the occipital lobe.
Methods: a 3-channel flexible, thin RF coil was constructed that allows for whole head image coverage without impeding TMS placement. A custom MR-safe patient table which mates with typical 3T MR scanners was constructed for the purpose of face-down subject positioning to allow for access to posterior TMS targets. To counterbalance the loading effect of the TMS coil on the RF coil circuits "Dummy Loads" are introduced, which mimic the loading conditions of the TMS coil when it is not present.
Results: the designed RF coil performed as expected, achieving acceptable SNR values at depths equal to the center of the average human head, and high SNR values near the surface.
Conclusion: The system allows for concurrent TMS-fMRI, targeting any area of the being while imaging the entire volume.
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http://dx.doi.org/10.1109/EMBC.2019.8857215 | DOI Listing |
bioRxiv
September 2024
Alto Neuroscience, Los Altos, CA, USA.
Neuroimaging and cognitive neuroscience studies have identified neural circuits linked to anxiety, mood, and trauma-related symptoms and focused on their interaction with the medial prefrontal default mode circuitry. Despite these advances, developing new neuromodulatory treatments based on neurocircuitry remains challenging. It remains unclear which nodes within and controlling these circuits are affected and how their impairment is connected to psychiatric symptoms.
View Article and Find Full Text PDFBiol Psychiatry Cogn Neurosci Neuroimaging
August 2024
Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany; Neuroimaging Core Unit Munich, LMU University Hospital, LMU Munich, Munich, Germany; German Center for Mental Health, Partner Site Munich-Augsburg, Germany.
Background: Intermittent theta burst stimulation (iTBS) of the dorsolateral prefrontal cortex (DLPFC) is widely applied as a therapeutic intervention in mental health; however, the understanding of its mechanisms is still incomplete. Prior magnetic resonance imaging (MRI) studies have mainly used offline iTBS or short sequences in concurrent transcranial magnetic stimulation (TMS)-functional MRI (fMRI). This study investigated a full 600-stimuli iTBS protocol using interleaved TMS-fMRI in comparison with 2 control conditions in healthy subjects.
View Article and Find Full Text PDFPhys Med Biol
August 2024
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
Transcranial magnetic stimulation (TMS) is a non-invasive method for stimulating the cortex. Concurrent functional magnetic resonance imaging can show changes in TMS-induced activity in the whole brain, with the potential to inform brain function research and to guide the development of TMS therapy. However, the interaction of the strong current pulses in the TMS coil in the static main magnetic field of the MRI produces high Lorentz forces, which may damage the coil enclosure and compromise the patient's safety.
View Article and Find Full Text PDFNeuroimage
June 2024
Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China; Mental Health Research Center (MHRC), The Hong Kong Polytechnic University, Hong Kong, China; Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria. Electronic address:
This systematic review investigates how prefrontal transcranial magnetic stimulation (TMS) immediately influences neuronal excitability based on oxygenation changes measured by functional magnetic resonance imaging (fMRI) or functional near-infrared spectroscopy (fNIRS). A thorough understanding of TMS-induced excitability changes may enable clinicians to adjust TMS parameters and optimize treatment plans proactively. Five databases were searched for human studies evaluating brain excitability using concurrent TMS/fMRI or TMS/fNIRS.
View Article and Find Full Text PDFNeuroimage
May 2024
Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany; Neuroimaging Core Unit Munich - NICUM, University Hospital, LMU Munich, Munich, Germany. Electronic address:
Background: Left prefrontal intermittent theta-burst stimulation (iTBS) has emerged as a safe and effective transcranial magnetic stimulation (TMS) treatment protocol in depression. Though network effects after iTBS have been widely studied, the deeper mechanistic understanding of target engagement is still at its beginning. Here, we investigate the feasibility of a novel integrated TMS-fMRI setup and accelerated echo planar imaging protocol to directly observe the immediate effects of full iTBS treatment sessions.
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