In this study, a novel multi-layer printed circuit board (PCB)-based neurostimulator system with an embedded microprocessor is presented for applications in neuroprosthesis. The system integrates rechargeable batteries, a power management block, adjustable constant-current waveforms, voltage transient monitoring, and evoked neural response recording. The system can be configured to select channels among the 16 stimulation channels via Bluetooth communication wirelessly. Bench top measurements demonstrated that the system generated biphasic current waveforms with various stimulation parameters with approximately 407 mW of power consumption. Additional testing and validation with microelectrodes are underway.
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http://dx.doi.org/10.1109/EMBC.2019.8856311 | DOI Listing |
Bioelectromagnetics
January 2025
Department of Electrical Engineering and ITEMS, University of Southern California, Los Angeles, California, USA.
As the clinical applicability of peripheral nerve stimulation (PNS) expands, the need for PNS-specific safety criteria becomes pressing. This study addresses this need, utilizing a novel machine learning and computational bio-electromagnetics modeling platform to establish a safety criterion that captures the effects of fields and currents induced on axons. Our approach is comprised of three steps: experimentation, model creation, and predictive simulation.
View Article and Find Full Text PDFPain Ther
January 2025
Robert Wood Johnson University Hospital/Rutgers Medical School, New Brunswick, NJ, USA.
Introduction: Many interventional strategies are commonly used to treat chronic low back pain (CLBP), though few are specifically intended to target the distinct underlying pathomechanisms causing low back pain. Restorative neurostimulation has been suggested as a specific treatment for mechanical CLBP resulting from multifidus dysfunction. In this randomized controlled trial, we report outcomes from a cohort of patients with CLBP associated with multifidus dysfunction treated with restorative neurostimulation compared to those randomized to a control group receiving optimal medical management (OMM) over 1 year.
View Article and Find Full Text PDFNeuroimage
January 2025
Institute for Human Neuroscience, Boys Town National Research Hospital, Boys Town, NE, USA; College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Department of Pharmacology & Neuroscience, Creighton University, Omaha, NE, USA. Electronic address:
Noninvasive brain stimulation of the primary motor cortex has been shown to alter therapeutic outcomes in stroke and other neurological conditions, but the precise mechanisms remain poorly understood. Determining the impact of such neurostimulation on the neural processing supporting motor control is a critical step toward further harnessing its therapeutic potential in multiple neurological conditions affecting the motor system. Herein, we leverage the excellent spatio-temporal precision of magnetoencephalographic (MEG) imaging to identify the spectral, spatial, and temporal effects of high-definition transcranial direct current stimulation (HD-tDCS) on the neural responses supporting motor control.
View Article and Find Full Text PDFNeuroimage
January 2025
College of Computer Science and Technology (College of Data Science), Taiyuan University of Technology, Taiyuan, 030024, China. Electronic address:
The brain, as a complex system, achieves state transitions through interactions among its regions and also performs various functions. An in-depth exploration of brain state transitions is crucial for revealing functional changes in both health and pathological states and realizing precise brain function intervention. Network control theory offers a novel framework for investigating the dynamic characteristics of brain state transitions.
View Article and Find Full Text PDFBrain Stimul
January 2025
Assistant Professor Co-Director, Center for Psychedelic Research and Therapy Department of Psychiatry & Behavioral Sciences Dell Medical School The University of Texas at Austin.
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