Standing from a seated position is an activity of daily living and a common clinical test of strength and balance. While this action is well-studied biomechanically, there remains a need for a clear modelling method for appropriately capturing performance and discriminating between standing strategies. This paper presents a simple framework for representing the rise from a chair as a set of splines. This formulation is inherently differentiable, defines a clear start and end point of the motion, and allows for secondary analysis of dynamic and energetic effects. This method is tested on two healthy subjects performing four different standing strategies. The spline method was found to accurately capture the standing action, with mean absolute errors of 1-2 cm for joint position, and 2-3 degrees angular error across the different standing strategies. Analysis of the spline trajectories revealed strategy-specific differences in kinematic, kinetic, and dynamic bio-markers. This suggests that low order splines can be used to accurately capture variations in sit-to-stand actions.
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http://dx.doi.org/10.1109/EMBC.2019.8857429 | DOI Listing |
Angew Chem Int Ed Engl
December 2024
Shanghai Institute of Technology, School of Chemical and Environmental Engineering, CHINA.
Laminating a free-standing carbon electrode film onto perovskite film is a promising method for fabricating HTM (hole transport material)-free carbon electrode perovskite solar cells (c-PSCs), offering more flexibility by decoupling the processes of carbon electrode and perovskite layer formation. However, the power conversion efficiency (PCE) of laminated HTM-free c-PSCs (<16.5%) remains lower compared to c-PSCs with printed carbon pastes (>20%), primarily due to poor interfacial contact between the perovskite and carbon layers.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia, insulin resistance, and decreased insulin secretion. With its rising global prevalence, effective management strategies are critical to reducing morbidity and mortality. This systematic review compares the efficacy, safety, and long-term outcomes of four major pharmacological treatments for T2DM: sodium-glucose cotransporter-2 (SGLT2) inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, metformin, and insulin.
View Article and Find Full Text PDFJ Family Med Prim Care
November 2024
Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India.
To effectively prevent cervical cancer, a leading cause of global morbidity and mortality among women, widespread adoption of the HPV vaccine has a well-established link to human papillomavirus (HPV) infection. HPV vaccine must be the vaccine's effectiveness in reducing HPV infections, and subsequent cervical lesions have been extensively demonstrated, marking a pivotal milestone in public health. Important research highlights the vaccine's safety profile, allaying worries and promoting trust in its application.
View Article and Find Full Text PDFCurr Protein Pept Sci
December 2024
Department of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh 201310, India.
TLR4 stands at the forefront of innate immune responses, recognizing various pathogen- associated molecular patterns and endogenous ligands, thus serving as a pivotal mediator in the immune system's defense against infections and tissue damage. Beyond its canonical role in infection, emerging evidence highlights TLR4's involvement in numerous non-infectious human diseases, ranging from metabolic disorders to neurodegenerative conditions and cancer. Targeting TLR4 signaling pathways presents a promising therapeutic approach with broad applicability across these diverse pathological states.
View Article and Find Full Text PDFJ Environ Manage
December 2024
FFPRI, 1 Matsunosato, Tsukuba, Ibaraki, 305-8687, Japan.
Planted forests have expanded globally over the last three decades and are expected to act as carbon sinks to mitigate further climate change. However, the planted coniferous forests in Japan are now predicted to shrink in area and age in the future. To quantify the impact of the shrinking and aging of Japanese cedar (Cryptomeria japonica D.
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