Electronic dental records (EDR) provide access to a vast repository of clinical information which may be used for analyzing dental care delivery. The goal of this study was identification of determinants of implant survival and development of implant failure prediction model using large data set of intact and failed implant parameters extracted from EDR. A retrospective analysis of 19 variables reflecting patient, surgeon and dental treatment characteristics of 800 dental implants was performed using discriminant analysis to develop a predictive model identifying potential implant failure based on characteristics routinely available in a clinical care setting. The intact and failed implant characteristics were compared using the Goodman and Kruskal's lambda test, the point-biserial test, the chi-square test, and ANOVA test. A stepwise discriminant analysis reduced model dimensionality from 19 to 4 features. The final discriminant analysis model included the following variables: non-temporary implant, pre-op antibiotics, immunocompromised status, and gender. Overall, 72% of implant failure cases and 62% of intact implants were correctly identified by the resulting discriminant function. As the final predictive feature set is readily available in EDR, the resulting algorithm may be implemented as a clinical decision support module embedded into EDR to promote personalized approach in dental implant patients.
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http://dx.doi.org/10.1109/EMBC.2019.8856783 | DOI Listing |
Nature
January 2025
German Centre for Cardiovascular Research (DZHK), Partner Site Lower Saxony, Göttingen, Germany.
Cardiomyocytes can be implanted to remuscularize the failing heart. Challenges include sufficient cardiomyocyte retention for a sustainable therapeutic impact without intolerable side effects, such as arrhythmia and tumour growth. We investigated the hypothesis that epicardial engineered heart muscle (EHM) allografts from induced pluripotent stem cell-derived cardiomyocytes and stromal cells structurally and functionally remuscularize the chronically failing heart without limiting side effects in rhesus macaques.
View Article and Find Full Text PDFAnn Chir Plast Esthet
January 2025
Department of Plastic and Reconstructive Surgery, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea.
Background: Unicortical plate fixation offers several theoretical advantages in the treatment of metacarpal shaft fractures compared to bicortical fixation. This approach avoids the potential hazard of excessive drilling into the volar cortex, thus minimizing damage to surrounding soft tissues and helping prevent complications related to improperly sized screws. These benefits prompted our team to conduct a preliminary clinical study to investigate the effectiveness and safety of this approach.
View Article and Find Full Text PDFJACC Clin Electrophysiol
January 2025
Cardioangiologisches Centrum Bethanien, Agaplesion Markus-Krankenhaus, Frankfurt am Main, Germany.
Background: The net benefit of oral anticoagulation in patients with end-stage renal disease on hemodialysis (HD) is uncertain. In recent years, left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation; however, there is scant evidence of LAAC in patients on HD.
Objectives: This study aimed to assess the feasibility and safety of LAAC in patients on HD.
Eur J Vasc Endovasc Surg
January 2025
Aortic Center, Hôpital Marie Lannelongue, GHPSJ, Le Plessis-Robinson, France. Electronic address:
Objective: The aim of this study was to perform a comparative pre-clinical evaluation of a new fenestrated endovascular aneurysm repair dedicated stent using perfused 3D printed patient anatomies.
Methods: The test setup included a pulsatile pump set to reproduce human haemodynamics, four 3D printed pararenal aneurysms connected to a bench test, and four corresponding fenestrated grafts (Zenith Fenestrated; Cook, Bloomington, IN, USA). Bridging stents were sized based on analysis of patients computed tomography scans and included either four standard covered stents (BeGraft [BG]; Bentley, Hechingen, Germany) or four similar covered stent grafts mounted on a modified balloon to allow stent implantation and flaring in one step (BeFlared [BF]; Bentley).
J Adv Res
January 2025
National Institute of Research and Development for Optoelectronics - INOE 2000, 409 Atomistilor St. 077125 Magurele, Romania. Electronic address:
Introduction: Chronic inflammation leading to implant failure present major challenges in orthopedics, dentistry, and reconstructive surgery. Titanium alloys, while widely used, often provoke inflammatory complications. Zinc-doped calcium phosphate (CaP) coatings offer potential to enhance implant integration by improving corrosion resistance, bioactivity, and immunocompatibility.
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