Understanding the contributions of therapist skill during intervention is essential for improving existing rehabilitation methodologies. This study aims to characterize therapist intervention on an important activity of daily living, the sit-to-stand motion. Using the concept of muscle synergy, we quantify and compare naturally-occurring standing strategies with those induced by a physical therapist. In this paper, we show that natural standing strategies are not shared among healthy subjects. However, each subject retains their own set of strategies. Moreover, the results suggest that a therapist does not introduce new strategies during therapy, but rather modulates the existing strategies of the individuals. Using such a low-dimensional representation of standing behavior allows for development of low-cost tools for wider distribution.
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http://dx.doi.org/10.1109/EMBC.2019.8857541 | DOI Listing |
Chin Med
January 2025
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China.
Background: Dilated cardiomyopathy (DCM) stands as one of the most prevalent and severe causes of heart failure. Inflammation plays a pivotal role throughout the progression of DCM to heart failure, while age acts as a natural predisposing factor for all cardiovascular diseases. These two factors often interact, contributing to cardiac fibrosis, which is both a common manifestation and a pathogenic driver of adverse remodeling in DCM-induced heart failure.
View Article and Find Full Text PDFSci Rep
January 2025
Unitat Mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), 08193, Bellaterra, Barcelona, Spain.
Vaccination stands as one of the most sustainable and promising strategies to control infectious diseases in animal production. Nevertheless, the causes for antibody response variation among individuals are poorly understood. The animal microbiota has been shown to be involved in the correct development and function of the host immunity, including the antibody response.
View Article and Find Full Text PDFNat Commun
January 2025
CAS Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China.
Developing active-layer systems with both high performance and mechanical robustness is a crucial step towards achieving future commercialization of flexible and stretchable organic solar cells (OSCs). Herein, we design and synthesize a series of acceptors BTA-C6, BTA-E3, BTA-E6, and BTA-E9, featuring the side chains of hexyl, and 3, 6, and 9 carbon-chain with ethyl ester end groups respectively. Benefiting from suitable phase separation and vertical phase distribution, the PM6:BTA-E3-based OSCs processed by o-xylene exhibit lower energy loss and improved charge transport characteristic and achieve a power conversion efficiency of 19.
View Article and Find Full Text PDFJ Environ Manage
January 2025
Ministry of Education Collaborative Innovation Center for Grassland Ecological Security, School of Ecology and Environment, Inner Mongolia University, Hohhot, 010021, China; Ministry of Education Key Laboratory of Ecology and Resource Use of the Mongolian Plateau & Inner Mongolia Key Laboratory of Grassland Ecology, School of Ecology and Environment, Inner Mongolia University, Hohhot, 010021, China. Electronic address:
Grassland represents one of the most expansive terrestrial ecosystems, exerting a profound influence on atmospheric greenhouse gas (GHG) levels within the broader context of global change. Both climate and land use changes play important roles in modulating grassland GHG emissions by directly or indirectly altering soil physical and chemical properties, especially soil temperature and inorganic nitrogen content. The optimal grassland management practices need to simultaneously meet the requirements of reducing GHG emissions, maintaining biological biodiversity, and ensuring productivity.
View Article and Find Full Text PDFAcc Chem Res
January 2025
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, China.
ConspectusThe Mannich reaction, involving the nucleophilic addition of an enol(ate) intermediate to an imine or iminium ion, is one of the most widely used synthetic methods for the synthesis of β-amino carbonyl compounds. Nevertheless, the homo-Mannich reaction, which utilizes a homoenolate intermediate as the nucleophilic partner and provides straightforward access to the valuable γ-amino carbonyl compounds, remains underexplored. This can be largely attributed to the difficulties in generation and manipulation of the homoenolate species, despite various homoenolate equivalents that have been developed.
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