This work proposes the use of Process Mining methodologies on healthcare datasets containing diagnosis information as a means to identify the course of a disease across organizations. Datasets containing diagnosis information for administrative purposes are a good candidate due to its standardized format, widespread availability and coverage. We present a methodology to preprocess, cluster and mine diagnosis information and the results of a preliminary use case with diabetes type II. Some meaningful disease courses have been found but less useful patterns do also emerge. Future work involves lowering the level of granularity chosen (ICD three digit codes) and extending the time span of the data available (three years).
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http://dx.doi.org/10.1109/EMBC.2019.8857149 | DOI Listing |
High-grade-B-cell lymphoma (HGBL) with MYC and BCL2 and/or BCL6 rearrangements (double hit [HGBL-DH] or triple hit [HGBL-TH]), or not otherwise specified (HGBL-NOS), are considered to be more aggressive diseases among large B-cell lymphomas (LBCL). CD19-targeting Chimeric Antigen Receptor (CAR) T-cells have changed the prognosis of chemoresistant LBCL. Clinical and pathological data of patients treated for relapsed/refractory LBCL or HGBL in third line or more, all characterized by FISH, were collected from the French DESCAR-T registry.
View Article and Find Full Text PDFPLoS One
January 2025
Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.
Adult neurogenesis has most often been studied in the hippocampus and subventricular zone-olfactory bulb, where newborn neurons contribute to a variety of behaviors. A handful of studies have also investigated adult neurogenesis in other brain regions, but relatively little is known about the properties of neurons added to non-canonical areas. One such region is the striatum.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Psychiatry, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
Background: Despite transcranial direct current stimulation (tDCS) has demonstrated encouraging potential for modulating the circadian rhythm, little is known about how well and sustainably tDCS might improve the subjective sleep quality in older adults. This study sought to determine how tDCS affected sleep quality and cognition, as well as how well pre-treatment sleep quality predicted tDCS effects on domain-specific cognitive functions in patients with mild neurocognitive disorder due to Alzheimer's disease (NCD-AD).
Methods: This clinical trial aimed to compare the effectiveness of tDCS and cognitive training in mild NCD-AD patients (n = 201).
PLoS One
January 2025
School of Life Course and Population Sciences, King's College London, London, United Kingdom.
Introduction: High-Flow Nasal Therapy (HFNT) is an innovative non-invasive form of respiratory support. Compared to standard oxygen therapy (SOT), there is an equipoise regarding the effect of HFNT on patient-centred outcomes among those at high risk of developing postoperative pulmonary complications after undergoing cardiac surgery. The NOTACS trial aims to determine the clinical and cost-effectiveness of HFNT compared to SOT within 90 days of surgery in the United Kingdom, Australia, and New Zealand.
View Article and Find Full Text PDFObjective: Aim: To investigate the peculiarities of deviations of preoperative values of biochemical markers of inflammation in the blood serum of patients with degenerative diseases of the lumbar spine after transpedicular fixation, with a complicated postoperative course to predict the development of various postoperative complications.
Patients And Methods: Materials and Methods: The content of glycoproteins (GP), sialic acids (SA), C-reactive protein (CRP), seroglicoids (SG), haptoglobin (HG), Veltman`s test (VT) were investigated. The results are comparable by the Student-Fisher method.
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