AI Article Synopsis
- Understanding how the structure of smart hydrogels affects their properties is essential for developing improved drug delivery systems.
- This study focuses on Pluronic smart hydrogels, highlighting their benefits such as better patient compliance, fewer side effects, and the ability to control drug release through phase changes within the body.
- Advanced techniques like small angle x-ray and neutron scattering are used to study the structural transitions of these hydrogels, helping to create empirical formulas for optimizing their performance as injectable drug carriers.
Article Abstract
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.
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| http://dx.doi.org/10.1016/j.jcis.2019.12.096 | DOI Listing |
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