AI Article Synopsis
- The study examined how different types of radiation (gamma and alpha from inhaled 239Pu) impact enzyme activity levels, specifically alanine-aspartate aminotransferase and lactate dehydrogenase.
- It was found that these enzyme activities change over time in a way that generally increases after exposure, depending on the radiation type and exposure duration.
- Importantly, the combined radiation effects did not surpass the total effects of the individual radiation types, indicating they have an additive effect rather than a synergistic one.
Article Abstract
After the effect of external gamma-radiation (6.5 to 51.6 mC/kg) and inhaled 239Pu submicron oxide, containing 25% of 241Am, (approximately 7 to 10 kBq/kg) delivered separately and in a combination, activities of alanine-aspartate aminotransferase and lactate dehydrogenase changed in an undulatory manner tending to increase at later times; the change rating was a function of type and level of radiation as well as the time lapsed from the onset of exposure. The combined effect of gamma- and alpha-radiation did not exceed the additive effect of the two factors delivered separately.
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