The regularities of the time course and intracellular distribution of estrogen receptors (ER) of the liver of ovariectomized female rats after a single injection of 1, 25 and 500 micrograms of E2 were investigated using new variants of a method of ligand exchange. The ER content in liver cells was 12275 +/- 1100 (n = 33) bonds per cell (by one order lower than in the uterus). A single injection of E2 at a dose of 1 micrograms caused no changes in the ER content in the liver cytosol and nuclear fractions whereas reciprocal redistribution of ER between the cytosol and nuclei was noted in the uterus. A single injection of 25 and 500 micrograms of E2 to ovariectomized female rats resulted in dose dependent ER redistribution between the cytosol and nuclear fractions, the development of "deficiency" of the total ER content in liver cells was also dose dependent. The main regularities of the time course and intracellular distribution of ER in the liver of ovariectomized female rats after a single injection of large doses of E2 were similar to those in common target organs for estrogens.
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