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Peripartum energy metabolism of prolific ewes and their progeny in response to prepartum feeding and litter size.
Animal
November 2024
Département des sciences animales, Université Laval, Pavillon Paul-Comtois, 2425 rue de l'Agriculture, Québec, QC, G1V 0A6, Canada. Electronic address:
In late gestation, the increased energy demand to support the rapid fetal growth can induce an acute negative energy balance associated with a high risk of pregnancy toxemia, especially for prolific ewes (carrying two or more fetuses). The current study was conducted to evaluate the effects of dietary energy during the last 6 weeks prepartum on the energy metabolism dynamic responses and the newborn lamb metabolic profile in prolific ewes. Forty-five crossbred (Dorset × Romanov) ewes were randomly assigned to 1 of 3 dietary energy densities: E: 8.
View Article and Find Full Text PDFSurface mold brachytherapy for head and neck non-melanoma skin cancer - local control rates and survival: A retrospective analysis.
J Contemp Brachytherapy
October 2024
Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: Non-melanoma skin cancer (NMSC) is the most prevalent cancer worldwide, particularly affecting head and neck region. Surgical excision, especially Moh's microsurgery, is the gold standard for treatment. However, certain patients' factors, such as age, comorbidities, and tumor location, require alternative therapies.
View Article and Find Full Text PDFEvaluating the feasibility of modern external beam radiotherapy as an alternative approach to brachytherapy in endometrial cancer treatment: A systematic review.
J Contemp Brachytherapy
October 2024
Radiation Oncology, Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum University of Bologna, Bologna, Italy.
Purpose: This systematic review aimed to assess the feasibility, safety, and efficacy of using modern external beam radiotherapy (EBRT) techniques, such as intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiotherapy (SBRT) as alternative approaches to brachytherapy (BRT) in adjuvant treatment of endometrial cancer (EC).
Material And Methods: A systematic review was conducted following PRISMA guidelines. The research question was framed using the PICO method, focusing on patients with EC [P] and comparing modern EBRT techniques (IMRT, VMAT, SBRT) [I] vs.
In-depth feasibility study on conservative surgery, perioperative high-dose-rate brachytherapy, and external beam radiation therapy, with a focus on interstitial brachytherapy for soft tissue sarcomas: Insights from a single-institute experience.
J Contemp Brachytherapy
October 2024
Department of Radiotherapy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Purpose: Soft tissue sarcomas (STS) due to their aggressive nature, pose challenges in achieving optimal local control (LC) rates following surgery. Brachytherapy offers precise delivery of high radiation doses to target tissues, potentially enhancing LC rates. This feasibility study explored the efficacy of perioperative high-dose-rate brachytherapy (PHDRB) and external beam radiation therapy (EBRT) in improving LC rates for STS, with a particular focus on interstitial brachytherapy and dose escalation strategies for high-risk patient sub-groups.
View Article and Find Full Text PDFHow I Treat AML relapse after allogeneic HCT.
Blood
December 2024
Dana-Farber Cancer Institute, BOSTON, Massachusetts, United States.
Allogeneic hematopoietic stem-cell transplantation (HCT) is one of the principal curative approaches in the treatment of acute myeloid leukemia (AML); however, relapse post-transplantation remains a catastrophic event with poor prognosis. The incidence of relapse has remained unchanged over the last three decades despite an evolving understanding of the immunobiology of the graft-versus leukemia effect and the immune escape mechanisms that lead to post-HCT relapse. The approach to post-transplant relapse is highly individualized and is dictated both by disease biology and genomics as well as the patient's clinical status at the time of relapse and the interval between relapse and transplantation.
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