Productivity and bioactivity of enokipodins A-D of and .

Enokipodins are antimicrobial sesquiterpenes produced by in a mycelial culture medium. To date, enokipodin production has not been reported in other members of the genus . Hence, in this study, the production of enokipodins A, B, C, and D by and was investigated. Some strains of were confirmed to produce at least one of the four enokipodins in the culture medium. However, some strains of did not produce any of the enokipodins. In an antibacterial assay using liquid medium, enokipodin B showed the strongest growth inhibitory activity against among the four types of enokipodins. Enokipodin B inhibited the spore germination of some plant pathogenic fungi. Enokipodins B and D exerted moderate anti-proliferative activity against some cancer cell lines, and enokipodins A and C inhibited the proliferation of the malarial parasite, .