Background: Lima is one of the more polluted cities in Latin America. High levels of PM have been shown to increase health center outpatient visits of respiratory diseases.
Methods: Health center outpatient visits for children < 5 years for childhood respiratory disease (acute lower respiratory infections (ALRI), pneumonia and acute bronchiolitis/asthma) from 498 public clinics in Lima were available on a weekly basis from 2011 to 2015 from Peru's Ministry of Health (MINSA). The association between the average weekly concentrations of PM was evaluated in relation to the number of weekly health center outpatient visits for children. Weekly PM values were estimated using a recently developed model that combined data observed from ground monitors, with data from space satellite and meteorology. Ground monitoring data came from 10 fixed stations of the Peruvian National Service of Meteorology and Hydrology (SENAMHI) and from 6 mobile stations located in San Juan de Miraflores by Johns Hopkins University. We conducted a time-series analysis using a negative binomial model.
Results: We found a significant association between exposure to PM and all three types of respiratory diseases, across all age groups. For an interquartile increase in PM, we found an increase of 6% for acute lower respiratory infections, an increase of 16-19% for pneumonia, and an increase of 10% for acute bronchiolitis / asthma.
Conclusions: Higher emissions of environmental pollutants such as PM could be a trigger for the increase of health center outpatients visits for respiratory diseases (ALRI, pneumonia and asthma), which are themselves risk factors for mortality for children in Lima province, Peru.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964058 | PMC |
http://dx.doi.org/10.1186/s12940-020-0564-5 | DOI Listing |
J Am Heart Assoc
February 2023
Helmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai New York NY.
Background The PINNACLE FLX (Protection Against Embolism for Non-valvular AF [Atrial Fibrillation] Patients: Investigational Device Evaluation of the Watchman FLX LAA [Left Atrial Appendage] Closure Technology) trial evaluated the safety and efficacy of a next-generation left atrial appendage closure device (WATCHMAN FLX; Boston Scientific, Marlborough, MA). At 1 year, the study met the primary end points of safety and anatomical efficacy/appendage closure. This final report of the PINNACLE FLX trial includes the prespecified secondary end point of ischemic stroke or systemic embolism at 2 years, also making it the first report of 2-year outcomes with this next-generation left atrial appendage closure device.
View Article and Find Full Text PDFJ Epidemiol Community Health
December 2011
Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Toyama 1-21-1, Shinjuku-ku, Tokyo, Japan.
Background: Few studies have examined the impact of weight change in different periods of lifetime on type 2 diabetes risk, and the association of weight loss with type 2 diabetes is unclear. We prospectively investigated the association of weight change since age 20 y and that during middle-to-late adulthood with the incidence of type 2 diabetes.
Methods: Subjects were 52,014 men and women aged 45-75 y who participated in the Japan Public Health Center-Based Prospective Study and had no history of diabetes.
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