AI Article Synopsis
- - RNA epigenetics is a cutting-edge area of research focusing on RNA modifications and their complex role in both normal and disease biology, particularly how they affect physiology and pathophysiology.
- - There are shared regulatory molecules between RNA and DNA/chromatin structures, but some are unique to RNA, indicating a distinct pathway for potential therapeutic targets.
- - The review aims to highlight RNA epigenetic changes that could lead to new treatments for cardiovascular disease, emphasizing their clinical relevance and potential for translation into therapies.
Article Abstract
RNA epigenetics is perhaps the most recent field of interest for translational epigeneticists. RNA modifications create such an extensive network of epigenetically driven combinations whose role in physiology and pathophysiology is still far from being elucidated. Not surprisingly, some of the players determining changes in RNA structure are in common with those involved in DNA and chromatin structure regulation, while other molecules seem very specific to RNA. It is envisaged, then, that new small molecules, acting selectively on RNA epigenetic changes, will be reported soon, opening new therapeutic interventions based on the correction of the RNA epigenetic landscape. In this review, we shall summarize some aspects of RNA epigenetics limited to those in which the potential clinical translatability to cardiovascular disease is emerging.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014325 | PMC |
| http://dx.doi.org/10.3390/ijms21020509 | DOI Listing |
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