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| http://dx.doi.org/10.1590/1516-3180.2018.030006082019 | DOI Listing |
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Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage.
Biomedicines
December 2024
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Background/objectives: The enzyme ubiquitin-specific protease 44 (USP44) is a deubiquitinating enzyme with identified physiological roles as a tumor suppressor and an oncogene. While some binding partners and substrates are known for USP44, the identification of other interactions may improve our understanding of its role in cancer. We therefore performed a proximity biotinylation study that identified products of several known cancer genes that are associated with USP44, including a novel interaction between BRCA2 and USP44.
View Article and Find Full Text PDFDetection of Partial Tandem Duplication by Optical Genome Mapping in Myeloid Neoplasms: Associated Cytogenetics, Gene Mutations, Treatment Responses, and Patient Outcomes.
Cancers (Basel)
December 2024
Department of Hematopathology, MD Anderson Cancer Center, The University of Texas, Houston, TX 77030, USA.
partial tandem duplication (PTD) involves intragenic duplications and has been associated with poorer prognosis. In this study, we evaluated PTD in 1277 patients with hematological malignancies using optical genome mapping (OGM). PTD was detected in 35 patients with acute myeloid leukemia (AML) (7%), 5 patients with myelodysplastic syndrome (MDS) (2.
View Article and Find Full Text PDFImpact of intraprostatic PSMA maximum standardised uptake value following prostatectomy: a systematic review and meta-analysis.
BJU Int
January 2025
Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Objective: To perform a systematic review and meta-analysis to assess the relationship between intraprostatic maximum standardised uptake value (SUV) of the dominant prostatic lesion as measured on preoperative prostate-specific membrane antigen (PSMA) positron emission tomography (PET) with radical prostatectomy International Society of Urological Pathology (ISUP) Grade Group, pathological tumour (pT) staging, and biochemical recurrence (BCR).
Methods: Prostate-specific membrane antigen PET may offer non-invasive assessment of histopathological and oncological outcomes before definitive treatment. SUV of the dominant lesion has been explored as a prognostic biomarker.
Pediatric Myeloid Neoplasms With UBTF Tandem Duplications: Morphologic, Immunophenotypic, and Clinical Characterization.
Am J Surg Pathol
January 2025
Department of Pathology, St. Jude Children's Research Hospital.
Article Synopsis
- Tandem duplications (TDs) in the UBTF gene are a recently identified genetic alteration linked to pediatric and adult acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), establishing UBTF-TD as a distinct subtype of AML.
- A study of 27 pediatric patients revealed that UBTF-TD is commonly associated with symptoms like cytopenia and characteristic changes in bone marrow, such as erythroid hyperplasia and trilineage dysplasia.
- The findings suggest that patients with MDS and AML exhibiting UBTF-TD have similar prognoses, indicating that both conditions may represent different manifestations of the same underlying disease.
Safety and cost of selective histopathological analysis for detecting cancer in surgical specimens: a systematic review.
ANZ J Surg
January 2025
Department of Surgery, The Univeristy of Adelaide, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia.
Article Synopsis
- The systematic review investigates the effectiveness and cost benefits of a selective histopathology approach for cancer detection, rather than the usual routine analysis of surgical specimens.
- It analyzed data from 11 studies involving over 26,000 patients who underwent various surgical procedures, identifying a low rate of cancer diagnoses but noting substantial cost savings.
- The conclusion emphasizes that while this selective method doesn’t significantly increase missed cancer diagnoses, there are concerns regarding legal protections for surgeons who opt out of routine histopathological analysis.
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