AI Article Synopsis
- The study investigates how ginsenoside Rg3 affects the expression of HIF-1α and VEGF in human gastric cancer cells under low oxygen conditions.
- Human gastric cancer BGC823 cells were tested under hypoxia, showing increased HIF-1α and VEGF levels, but Rg3 treatment significantly reduced these levels compared to the control group.
- The findings suggest that Rg3 could potentially hinder gastric cancer metastasis by inhibiting the expression of HIF-1α and VEGF.
Article Abstract
Objective: The aim of this study is to probe in the inhibitory effects of ginsenoside Rg3 on the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human gastric cancer cells.
Materials And Methods: Human gastric cancer BGC823 cells were divided into the control group and experiment group, and expression levels of HIF-1α and VEGF were detected by immunocytochemistry and Western blot after cells were cultured under hypoxia for different durations.
Results: Under hypoxia, expression of HIF-1α and VEGF in human gastric cancer BGC823 cells showed an increasing trend, and that was remarkably lower in experiment group than in the control group after applying Rg3, which was obvious at 12 and 24 h (P < 0.05).
Conclusion: Rg3 can inhibit expression of HIF-1α and VEGF in human gastric cancer cells and may influence abdominal implantation metastasis of gastric cancer through inhibiting its expression.
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| http://dx.doi.org/10.4103/jcrt.JCRT_77_17 | DOI Listing |
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