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Identification of Southeast Asian Anopheles mosquito species with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a cross-correlation approach.
Parasit Vectors
January 2025
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Ramat, Thailand.
Background: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is proposed for mosquito species identification. The absence of public repositories sharing mass spectra and open-source data analysis pipelines for fingerprint matching to mosquito species limits the widespread use of this technology. The objective of this study was to develop a free open-source data analysis pipeline for Anopheles species identification with MALDI-TOF MS.
View Article and Find Full Text PDFAntimicrobial Susceptibility Patterns and Antimicrobial Therapy of Infections Caused by Species.
Medicina (Kaunas)
December 2024
Department of Internal medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan.
: species have become significant sources of infections acquired in hospital settings and are commonly linked to high mortality rates. Antimicrobial resistance can be influenced by species, geographical location, antimicrobial susceptibility testing methods, and the time of bacterial isolation. There are distinct antimicrobial susceptibility patterns among species, and the investigation into potential antibiotic susceptibility variations among species is beneficial.
View Article and Find Full Text PDFGametocyte production and transmission fitness of African and Asian isolates with differential susceptibility to artemisinins.
bioRxiv
December 2024
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen, The Netherlands.
The emergence of parasites partially resistant to artemisinins (ART-R) poses a significant threat to recent gains in malaria control. ART-R has been associated with PfKelch13 (K13) mutations, which differ in fitness costs. This study investigates the gametocyte production and transmission fitness of African and Asian isolates with different K13 genotypes across multiple mosquito species.
View Article and Find Full Text PDFNovel isothermal nucleic acid amplification method for detecting malaria parasites.
Appl Microbiol Biotechnol
December 2024
Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz (IOC), Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, Brazil.
Article Synopsis
- Malaria, caused by Plasmodium spp. and transmitted by Anopheles mosquitoes, remains a significant global health threat, with 249 million cases and 608,000 deaths reported in 2022.
- The study evaluated the GENEYE® ERA Plasmodium detection kit for rapid and accurate malaria diagnosis in the Brazilian Amazon, comparing it with traditional methods like microscopy and rapid diagnostic tests (RDT).
- Results indicated that the ERA test demonstrated 100% sensitivity alongside qPCR, while microscopy and RDT had lower sensitivity, highlighting the need for improved diagnostic tools in malaria-endemic regions.
mosquito exposure is associated with age, gender and bed net use in areas in Uganda experiencing varying malaria transmission intensity.
medRxiv
December 2024
Department of Medical Microbiology, Radboud University Medical Centre, Nijmegen.
Objectives: The number of mosquito bites a person receives determines the risk of acquiring malaria and the likelihood of transmitting infections to mosquitoes. We assessed heterogeneity in biting and associated factors in two settings in Uganda with different endemicity.
Methods: parasites in blood-fed indoor caught mosquitoes were quantified using qPCR targeting the Pf18S rRNA gene.
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