Losartan is a common first-line antihypertensive medication particularly useful in a select patient population. Common side effects of the drug include headaches, dizziness, fatigue, nausea, vomiting, and anemia. The only well-documented detrimental side effect of losartan is angioedema/anaphylactoid reactions. Here, we present a case of a 56-year-old Caucasian male who developed tremors and dysarthria one hour after taking losartan. His symptoms were severe enough to require hospitalization and close monitoring. His symptoms later resolved without any targeted treatment. This is the first reported case of tremors and dysarthria associated with the use of losartan which could represent an entirely benign side effect or an initial sequela of a potentially detrimental side effect that warrants our attention.
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http://dx.doi.org/10.7759/cureus.6374 | DOI Listing |
Cerebellum
December 2024
School of Medicine, University of Notre Dame, Sydney, NSW, Australia.
Clinically-relevant variants in the STUB1 gene have been associated with an autosomal dominant spinocerebellar ataxia 48 (SCA48), a recently described inherited neurodegenerative condition that is characterised by cognitive and psychiatric changes. To describe the clinical phenotype and genetic findings of three new Australian probands with STUB1 to expand the current understanding of the spectrum of clinical presentation and natural history of SCA48. Clinical and genetic review of patients diagnosed with SCA48 ataxia drawn from our centres.
View Article and Find Full Text PDFCan J Neurol Sci
December 2024
Krembil Brain Institute, Toronto, Ontario, Canada.
Background: There is limited information on rare spinocerebellar ataxia (SCA) variants, particularly in the Canadian population. This study aimed to describe the demographic and clinical features of uncommon SCA subtypes in Canada and compare them with international data.
Methods: We conducted a case series and literature review of adult patients with rare SCA subtypes, including SCA5, SCA7, SCA12, SCA14, SCA15, SCA28, SCA34, SCA35 and SCA36.
Sci Rep
November 2024
Dongzhimen Hospital Beijing University of Chinese Medicine, No.5 Haiyun Cang, Dongcheng District, Dermatology, Beijing, Beijing, 100700, China.
Famciclovir, mainly used to treat herpes zoster, is rapidly transforms into penciclovir when administered orally. Our study evaluated adverse events (AEs) associated with famciclovir by mining data from the publicly available Food and Drug Administration Adverse Event Reporting System (FAERS) database, providing a reference for clinical safety. Disproportionality analysis (including reported odds ratio and proportional reporting ratio) and Bayesian methods (including Bayesian Confidence Propagation Neural Network and Gamma-Poisson Shrinkage) were used to quantify the AE signals associated with famciclovir.
View Article and Find Full Text PDFNeurosurg Focus
November 2024
2Expert Center for Parkinson's Disease, Amiens Picardie University Hospital, Amiens.
Acta Neurol Belg
November 2024
Department of Neuroscience and Padova Neuroscience Center (PNC), University of Padova, Padua, Italy.
Background And Purpose: Ataxia, tremors, dysarthria, and sometimes impaired cognition are the signs of cerebellum involvement in multiple sclerosis (MS). These symptoms affect up to 80% of patients and are usually hard to treat. To find the underlying involvement of the cerebellum in MS, we assessed the microstructural alterations with DTI in the cerebellar peduncles of the affected subjects.
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