AI Article Synopsis
- The study explores the role of long non-coding RNA (lncRNA) UCHL1-AS1 in hepatocellular carcinoma (HCC), focusing on its biological functions and molecular mechanisms.
- UCHL1-AS1 was found to inhibit the migration of HCC cells, but it did not significantly affect cell proliferation.
- Key genes like BMP4, CALM3, and HRAS were identified as important in the context of UCHL1-AS1, suggesting potential pathways that could be targeted for better prognosis and treatment of HCC.
Article Abstract
We set out to investigate biological functions and potential molecular mechanisms of long non-coding RNA (lncRNA) in hepatocellular carcinoma (HCC). HCC cell line Bel-7404 was cultured and transfected with antisense to the ubiquitin carboxyl-terminal hydrolase L1 (UCHL1-AS1). Viability and mobility were detected by MTT and wound healing assays. Additionally, enrichment analysis and functional networks of UCHL1-AS1 related genes in HCC were performed. Results showed that high level UCHL1-AS1 could effectively inhibit HCC cell migration. However, there was no significant correlation between overexpressed UCHL1-AS1 and HCC proliferation. Meanwhile, BMP4, CALM3, and HRAS were selected from 204 genes that related to UCHL1-AS1. All of these hub genes play critical roles in HCC occurrence and development. Thus, underlying molecular mechanisms among hub genes and UCHL1-AS1 in HCC might be valuable for prognosis and treatment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958276 | PMC |
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