Hepatocellular carcinoma (HCC) is the most common primary liver cancer, ranking as the second leading cause of male cancer death worldwide. MicroRNA-29 (miR-29) has been demonstrated to act as a tumor suppressor in HCC. However, the regulatory mechanism of miR-29 underlying HCC growth and metastasis still remains obscure. In the present study, we showed that the expression of miR-29 was significantly reduced in HCC tissues and cell lines, and low miR-29 expression was associated with disease progression and shorter survival time of HCC patients. In vitro experiments showed that restoration of miR-29 expression caused a significant reduction in HCC cell proliferation, migration and invasion. Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was identified as a novel target gene of miR-29. The expression of IGF2BP1 was significantly increased in HCC tissues and cell lines. Moreover, IGF2BP1 was negatively regulated by miR-29 at the post-transcriptional levels in HCC cells. Furthermore, overexpression of IGF2BP1 attenuated the suppressive effects of miR-29 on the proliferation, migration, and invasion of HCC cells. According to these above findings, our study suggests that miR-29 may play a suppressive role in HCC growth and metastasis through directly targeting IGF2BP1. Therefore, miR-29 may be used as a potential candidate for the treatment of HCC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958137 | PMC |
Publication Analysis
Top Keywords
Similar Publications
The microRNA-29ab1/Zfp36/AR Axis in the Hypothalamus Regulates Male-Typical Behaviors in Mice.
Int J Mol Sci
December 2024
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Male-typical behaviors such as aggression and mating, which reflect sexual libido in male mice, are regulated by the hypothalamus, a crucial part of the nervous system. Previous studies have demonstrated that microRNAs (miRNAs), especially , play a vital role in reproduction and the neural control of behaviors. However, it remains unclear whether affects reproduction through the hypothalamus-mediated regulation of male-typical behaviors.
View Article and Find Full Text PDFHuman Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Loaded Mir-29-3p Targets AhR to Improve Juvenile Idiopathic Arthritis via Inhibiting the Expression of IL-22 in CD4 T Cell.
Stem Cell Rev Rep
December 2024
Pediatric Immunology and Rheumatology Department, School of Medicine, Chief Physician, Chengdu Women's and Children's Central Hospital, University of Electronic Science and Technology of China, No.1617, Riyue Avenue, Qingyang District, Chengdu, Sichuan, China.
Article Synopsis
- Juvenile idiopathic arthritis (JIA) is a common chronic inflammatory disease in children, and this study explores how human umbilical cord mesenchymal stem cell-derived exosomes (HUCMSCs-Exos) influence JIA by delivering miR-29-3p to inhibit IL-22 expression in T cells.
- In experiments with a collagen-induced arthritis mouse model and JIA patient T cells, results showed that HUCMSCs-Exos significantly reduced IL-22 levels while increasing miR-29-3p levels, reversing the expression of related genes in T cells.
- Ultimately, the study concludes that HUCMSCs-Exos targeting AhR through miR-29-3p may offer a
Qingrexiaoji Recipe Regulates the Differentiation of M2 TAM miR-29 in GC.
Comb Chem High Throughput Screen
October 2024
Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Background: Gastric cancer, one of the most familiar adenocarcinomas of the gastrointestinal tract, ranks third in the world in cancer-related deaths. Traditional Chinese medicine can suppress the growth of tumors, and the underlying mechanism may be associated with the tumor microenvironment. Here, we investigated the anti-cancer effects of the Qingrexiaoji recipe on gastric cancer and the underlying molecular mechanism.
View Article and Find Full Text PDFMicroRNAs and human viral diseases: A focus on the role of microRNA-29.
Biochim Biophys Acta Mol Basis Dis
January 2025
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. Electronic address:
The viral replication can impress through cellular miRNAs. Indeed, either the antiviral responses or the viral infection changes through cellular miRNAs resulting in affecting many regulatory signaling pathways. One of the microRNA families that is effective in human cancers, diseases, and viral infections is the miR-29 family.
View Article and Find Full Text PDFDown-regulation of miR-29 improves lipid metabolism in fatty liver of dairy cows.
Anim Biotechnol
November 2024
State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun Jilin, China.
Article Synopsis
- This study explores how miR-29 affects lipid metabolism in dairy cows by categorizing 32 cows into groups based on liver triglyceride content: healthy, mild fatty liver, and moderate fatty liver.
- Dairy cows with moderate fatty liver exhibited increased lipid buildup and elevated liver enzyme levels, while healthy calves had isolated hepatocytes tested with sodium oleate under different conditions.
- The results indicated that inhibiting miR-29 reduced lipid accumulation and liver enzyme levels, suggesting that miR-29 could be integral to understanding fatty liver disease in dairy cows.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!