AI Article Synopsis
- UV exposure leads to increased reactive oxygen species and the production of matrix metalloproteinases, contributing to skin aging (photoaging).
- The study focused on testing a probiotic fermented plant extract (PELB) found in Kimchi for its potential anti-photoaging properties in skin cells exposed to UVB radiation.
- Results showed that PELB not only reduced elastase and collagenase activity but also increased collagen levels and antioxidant enzyme expression, indicating its potential as an effective ingredient in cosmetic products for UV-related skin protection.
Article Abstract
Ultraviolet (UV) exposure triggers the abnormal production of reactive oxygen (ROS) species and the expression of matrix metalloproteinases (MMPs) that are responsible for photoaging. Probiotics are widely used in healthcare and for immune enhancement. One probiotic, is found in Kimchi. This study was aimed at assessing the anti-photoaging effect of plant extracts fermented with (PELB) to develop functional cosmetics. We investigated the anti-photoaging effect of PELB in a UVB-induced photoaging in vitro model and selected effective extracts using the elastase inhibition assay, ELISA for Type I procollagen and collagenase-1, and quantitative real time PCR. Normal human dermal fibroblasts and epidermal keratinocytes were pre-treated with PELB and exposed to UVB. We found that PELB decreased elastase activity and increased type I collagen expression in a UVB-induced photoaging in vitro model. In addition, PELB greatly reduced collagenase activity and MMP mRNA levels in a UVB-induced photoaging in vitro model. Furthermore, PELB promoted the expression of moisture factor and anti-oxidant enzymes in a UVB-induced photoaging in vitro model. These results indicated that the PELB could be potential candidates for the protective effects against UVB-induced photoaging. Overall, these results suggest that PELB might be useful natural components of cosmetic products.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151581 | PMC |
| http://dx.doi.org/10.3390/jfb11010003 | DOI Listing |
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