AI Article Synopsis

  • The size and surface characteristics of nanoparticles play a crucial role in improving drug binding, organ distribution, and targeting specific tumors for effective cancer treatment.
  • The study utilized different modified nanoparticles as carriers for anticancer drugs in a murine breast cancer model, revealing significantly greater tumor regression with the α-ketoglutaric acid-modified nanoparticles compared to direct drug application.
  • Results showed that these nanoparticles not only increased drug accumulation in blood and tumors but also reduced heart toxicity, suggesting their potential as effective and safer drug delivery systems in breast cancer therapy.

Article Abstract

The morphology, size, and surface area of nanoparticles (NPs), with the existence of functional groups on their surface, contribute to the drug binding affinity, distribution of the payload in different organs, and targeting of a particular tumor for exerting effective antitumor activity in vivo. However, the inherent chemical structure of NPs causing unpredictable biodistribution with a toxic outcome still poses a serious challenge in clinical chemotherapy. In this study, carbonate apatite (CA), citrate-modified CA (CMCA) NPs, and α-ketoglutaric acid-modified CA (α-KAMCA) NPs were employed as carriers of anticancer drugs for antitumor, pharmacokinetic, and toxicological analysis in a murine breast cancer model. The results demonstrated almost five-fold enhanced tumor regression in the cyclophosphamide (CYP)-loaded α-KAMCA NP-treated group compared to the group treated with CYP only. Also, NPs promoted much higher drug accumulation in blood and tumor in comparison with the drug injected without a carrier. In addition, doxorubicin (DOX)-loaded NPs exhibited less accumulation in the heart, indicating less potential myocardial toxicity in mice compared to free DOX. Our findings, thus, conclude that CA, CMCA, and α-KAMCA NPs extended the circulation half-life and enhanced the anticancer effect with reduced toxicity of conventional chemotherapeutics in healthy organs, signifying that they are promising drug delivery devices in breast cancer treatment.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017074PMC
http://dx.doi.org/10.3390/cancers12010161DOI Listing

Publication Analysis

Top Keywords

carbonate apatite
8
anticancer drugs
8
α-kamca nps
8
breast cancer
8
nps
7
krebs cycle
4
cycle intermediate-modified
4
intermediate-modified carbonate
4
apatite nanoparticles
4
nanoparticles drastically
4

Similar Publications

Mild hypophosphatasia (HPP) can be difficult to distinguish from other bone disorders in the absence of typical symptoms such as the premature loss of primary teeth. Therefore, this study aimed to analyze the crystallinity of hydroxyapatite (HAp) and the three-dimensional structure of collagen in HPP teeth at the molecular level and to search for new biomarkers of HPP. Raman spectroscopy was used to investigate the molecular structure, composition, and mechanical properties of primary teeth from healthy individuals and patients with HPP.

View Article and Find Full Text PDF

Deciphering the mineral code of urinary stones: A first look at zinc isotopes.

Environ Pollut

December 2024

Nu Instruments, Wrexham Industrial Estate, 74 Clywedog Road South, Wrexham, LL13 9XS, United Kingdom.

Zinc (Zn) is an essential element for all living organisms, and Zn isotopes play a key role in studying the formation of disease. Despite extensive studies on Zn isotopes in healthy and diseased human tissues, the role of Zn isotopes in urinary stones remains unexplored. This study investigates Zn isotopes in 37 urinary stones using multi-collector inductively coupled plasma mass spectrometry.

View Article and Find Full Text PDF

Naked siRNAs are sensitive to enzymatic degradation, phagocytic entrapment, quick renal excretion, membrane impermeability, endosomal escape, and off-target effects. Designing a safe and efficient nanocarrier for siRNA delivery to the target site without toxicity remains a significant hurdle in gene therapy. CA is a unique derivative of hydroxyapatite and a highly pH-sensitive nanocarrier with strong particle aggregation and a high polydispersity index.

View Article and Find Full Text PDF

Purpose: To evaluate the effectiveness of COAp granules in the mandibular bone defects by using computed tomography (CT) images.

Methods: This study was retrospective case series of mandibular bone defect reconstruction using COAp granules. Six patients with jawbone cysts treated by simultaneous grafting COAp granules after cyst enucleation were enrolled.

View Article and Find Full Text PDF

Aims: This preclinical study aimed to evaluate the periodontal tissue regenerative capacities of poly (lactic acid/caprolactone) (PLCL) bilayer membrane in one-wall intrabony defects in dogs. No study has assessed the efficacy of PLCL bilayer membrane for periodontal regeneration therapy despite the fact that PLCL bilayer membrane has proved efficient for bone regeneration.

Methods: In five beagle dogs, the bilateral mandibular second and fourth premolars were extracted 8 weeks before the experimental surgery.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!