Plant endophytes are microbial sources of bioactive secondary metabolites, which mimic the natural compounds chemistry of their respective host plants in a similar manner. This study explored the isolation and identification of fungal endophytes, and investigated the antibacterial and antimycobacterial activity of their crude extracts. Fungal endophytes were isolated from , identified using morphological traits and internal transcribed spacer ribosomal-deoxyribonucleic acid (ITS-rDNA) sequence analysis. Eight fungal endophytes were identified as , sp., sp., sp., and sp., while was isolated from the leaves and unripe fruits. Good activity was observed for the crude extracts of inhibiting , and at 6 µg/mL. Crude extracts of sp., showed activity at 9 μg/mL against and . In general, the crude extracts showed great activity against Gram-negative and Gram-positive bacteria and novel results for two mycobacteria species and . The results provide evidence of diverse fungal endophytes isolated from and evidence that fungal endophytes are a good source of bioactive compounds with pharmaceutical potential, particularly against
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013891 | PMC |
http://dx.doi.org/10.3390/ijerph17020439 | DOI Listing |
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