AI Article Synopsis
- This study investigates the role of long non-coding RNA (lncRNA-SNHG3) in intrahepatic cholangiocarcinoma (ICC) and its potential as a prognostic indicator.
- LncRNA microarray assays and RT-qPCR showed that SNHG3 levels were significantly higher in ICC tissues compared to non-tumorous tissues, with higher levels linked to shorter overall survival (OS) for patients.
- The findings suggest that SNHG3 could serve as an independent prognostic factor and may help develop new therapeutic strategies for treating ICC.
Article Abstract
Background: Numerous deregulated long non-coding RNAs (lncRNAs) accompany the initiation and progression of carcinogenesis. The present study aimed to explore the prognostic significance of lncRNA-SNHG3 on intrahepatic cholangiocarcinoma (ICC) patients.
Methods: LncRNA microarray assays were used to evaluate lncRNA expression profiling in three pairs of ICC tissues and adjacent non-tumorous tissues. RT-qPCR was performed to further validate the accuracy of the microarray results.
Results: lncRNA microarray and RT-qPCR assays revealed that SNHG3 expression levels were significantly increased in ICC tissues compared to the adjacent non-tumor tissues. A high SNHG3 expression level was significantly correlated with shorter OS in ICC patients. A multivariate regression analysis discovered that SNHG3 could serve as an independent prognostic factor for predicting the OS of ICC patients.
Conclusion: We found SNHG3 to be an independent risk factor for predicting the prognosis of ICC. SNHG3 shows a strong promise in the development of novel therapeutic targets for the treatment of ICC.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949551 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!