AI Article Synopsis
Article Abstract
Objective: To investigate the role of microsatellite instability (MSI) in the pathogenesis of gastric carcinoma and its relationship with the expression of hTERT gene.
Methods: 75 cases of gastric carcinoma and paired normal control tissues were included in this study. MSI of BAT-25, BAT-26, D5S346, D17S250 and D2S1235 were detected by PCR, native polyacrylamide gel electrophoresis, and silver staining while the expression of hTERT was localized by immunohistochemistry at the same time.
Results: MSI positive rates of BAT-25, BAT-26, D5S346, D17S250 and D2S123 were 14.7%, 12.00%, 26.67%, 16% and 21.3%. MSI was obviously related with lymph node metastasis and pathologic stages respectively (P<0.05), but not with age, gender, histologic type, or infiltration depth (P>0.05). hTERT was not expressed in normal gastric mucosa, but in intestinal metaplasia, dysplasia, and gastric carcinoma. The positive rate of hTERT was 76% (57/75) in 75 cases of gastric carcinoma tissues. The expression of hTERT was obviously related to histological type (P<0.05), but not to age, gender, lymph node metastasis, depth of invasion, or staging, respectively (P>0.05). The positive rate was higher in poorly differentiated cases than in moderately and well differentiated cases (P<0.05). MSI accounted for 28.1% of 57 hTERT positive cases while MSI accounted for 72.2% in 18 hTERT negative cases. Spearman rank correlation analysis showed that MSI was negatively related to hTERT expression (r=0.387, P=0.001).
Conclusion: MSI may play an important role in the pathogenesis and progression of gastric carcinoma by affecting the expression of TERT gene.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949629 | PMC |
Publication Analysis
Top Keywords
Similar Publications
[Gastric adenocarcinoma complicated by subarachnoid hemorrhage and cerebral infarction: a rare case of Trousseau syndrome and literature review].
Zhonghua Nei Ke Za Zhi
February 2025
Department of Neurology, the Eighth Medical Center of Chinese PLA General Hospital, Beijing100091, China.
Trousseau's syndrome is a thromboembolic disorder associated with malignancies, with cerebral infarction and hemorrhage representing common central nervous system complications in patients with cancer. This report details the diagnosis and treatment of a patient with gastric adenocarcinoma at our institution who concurrently developed cerebral infarction and subarachnoid hemorrhage. We performed a comprehensive literature review in the Wanfang and PubMed databases, searching for relevant studies on Trousseau's syndrome, cerebral embolism, and subarachnoid hemorrhage.
View Article and Find Full Text PDFPLASMA: Partial LeAst Squares for Multiomics Analysis.
Cancers (Basel)
January 2025
Department of Biostatistics, Data Science, and Epidemiology, School of Public Health, Georgia Cancer Center at Augusta University, Augusta, GA 30912, USA.
: Recent growth in the number and applications of high-throughput "omics" technologies has created a need for better methods to integrate multiomics data. Much progress has been made in developing unsupervised methods, but supervised methods have lagged behind. : Here we present the first algorithm, PLASMA, that can learn to predict time-to-event outcomes from multiomics data sets, even when some samples have only been assayed on a subset of the omics data sets.
View Article and Find Full Text PDFHarnessing Machine Learning and Nomogram Models to Aid in Predicting Progression-Free Survival for Gastric Cancer Patients Post-Gastrectomy with Deficient Mismatch Repair(dMMR).
BMC Cancer
January 2025
Department of Gastroenterology, Shanxi Hospital Affiliated to Carcinoma Hospital, Chinese Academy of Medical SciencesShanxi Province Carcinoma Hospital, Carcinoma Hospital Affiliated to Shanxi Medical University, Taiyuan, Shanxi, 030013, People's Republic of China.
Objective: To assess the effectiveness of a machine learning framework and nomogram in predicting progression-free survival (PFS) post-radical gastrectomy in patients with dMMR.
Method: Machine learning models and nomograms to forecast PFS in patients undergoing radical gastrectomy for nonmetastatic gastric cancer with dMMR. Independent risk factors were identified using Cox regression analysis to develop the nomogram.
Corrigendum to "Xiao Tan He Wei decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: Regulation of apoptosis through NF-κB pathway"[Biomed. Pharmacother. 108 (2018) 95-102].
Biomed Pharmacother
January 2025
Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. Electronic address:
Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands.
Vet Sci
January 2025
Department of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The Netherlands.
Background: Gastric carcinoma in the Tervueren and Groenendael varieties of the Belgian Shepherd dog is commonly recognized and carries a grave prognosis. Information on incidence and heritability is necessary to design an effective selection strategy against this disease.
Methods: A database of cases and controls was built including cases with Tier 1 (confirmed via endoscopy or post-mortem) and Tier 2 evidence of gastric carcinoma.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!