Influence of electrical field during crystallization on dielectric constant, zeta potential and oxidation and reduction properties of paracetamol.

The crystals of paracetamol obtained by exposure of its saturation solution to DC electric field of varying duration (1-6 min) supplied by means of silver electrodes (the term coined as ENS-crystals). These ENS-crystals were analyzed for electrical properties such as dielectric constant, zeta potential, electrochemical properties such as oxidation and reduction potential (EP), current (iP), and charges (Ah) means of cyclic voltammetry. The dielectric constant is increased at 1 kHz and 100 kHz frequencies. Zeta potential is also enhanced by significant degree. Cyclic voltametric analysis reveals that the oxidizing potential and charge of paracetamol ENS-crystal is enhances by two fold. Quantitatively these changes are dependent on the duration of exposure to electrical field from 1 to 6 min. These changes in electrical and electrochemical properties of paracetamol ENS-crystals could be useful from the pharmaceutical point of view.