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Negative Symptoms in Schizophrenia: An Update on Research Assessment and the Current and Upcoming Treatment Landscape.
CNS Drugs
January 2025
New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
Article Synopsis
- The negative symptoms of schizophrenia, like lack of emotion and motivation, are hard to treat and significantly impact daily functioning.
- This review highlights current research on treatment options for these symptoms, categorizing them into different types and evaluating various assessment scales.
- Although no treatments are conclusively proven as the best for these symptoms, some off-label and investigational medications show promise, including cariprazine and memantine, and further research is needed to explore new therapeutic possibilities.
Quantifying the portrayal of alcohol-related A&E attendances and prevention in the British medical documentary series '24 hours in A&E'.
J Public Health (Oxf)
January 2025
Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham NG5 1PB, UK.
Background: Alcohol misuse is linked to numerous health and socioeconomic harms. Edutainment and docutainment television programmes can act as health promotion tools, influencing health perceptions and behaviours. Inaccurate portrayals can engender misinformation.
View Article and Find Full Text PDFAXL: shapers of tumor progression and immunosuppressive microenvironments.
Mol Cancer
January 2025
Department of Respiratory Disease, Daping Hospital, Army Medical University, Chongqing, 400042, China.
As research progresses, our understanding of the tumor microenvironment (TME) has undergone profound changes. The TME evolves with the developmental stages of cancer and the implementation of therapeutic interventions, transitioning from an immune-promoting to an immunosuppressive microenvironment. Consequently, we focus intently on the significant role of the TME in tumor proliferation, metastasis, and the development of drug resistance.
View Article and Find Full Text PDFAccuracy of the National Early Warning Score version 2 (NEWS2) in predicting need for time-critical treatment: retrospective observational cohort study.
Emerg Med J
January 2025
Yorkshire Ambulance Service NHS Trust, Wakefield, UK.
Background: Initial ED assessment can use early warning scores to identify and prioritise patients who need time-critical treatment. We aimed to determine the accuracy of the National Early Warning Score version 2 (NEWS2) for predicting the need for time-critical treatment.
Methods: We undertook a single-centre retrospective observational cohort study.
Assessing Long-Term Outcomes after Operative Management of Elbow Stiffness Secondary to Heterotopic Ossification.
J Shoulder Elbow Surg
January 2025
Department of Orthopaedic Surgery and Rehabilitation, Loyola University Health System, Maywood, IL, USA.
Article Synopsis
- Heterotopic ossification (HO) in the elbow leads to limited movement and is often caused by injuries like burns or trauma; this study analyzes the long-term outcomes of 51 elbows treated surgically.
- The study followed 48 patients over an average of 8 years, assessing metrics such as elbow movement arcs, pain levels, and functional performance scores post-surgery.
- Results showed significant improvement in elbow functionality, but patients with type II diabetes experienced the lowest movement range and higher complication rates, indicating potential risk factors for poorer outcomes.
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