AI Article Synopsis
- Vaginal candidiasis is common in pregnant women, with a study finding that 39% tested positive for Candida species, primarily C. albicans, C. glabrata, and C. krusei.
- The research showed significant associations between C. albicans and gestational diabetes, while other strains like C. glabrata and C. krusei were linked to various gestational complications.
- Antifungal susceptibility testing indicated high effectiveness of common antifungals against C. albicans, suggesting that routine screening could help reduce risks for mothers and their babies.
Article Abstract
Background: Vaginal candidiasis is frequent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the prevalence of candida species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated Candida strains. It also aimed to explore whether Candida species predicts gestational complications and adverse neonatal outcomes.
Methods: A total of 258 pregnant women with vaginal discharge at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 14 months. Candida isolates were identified at species level and antifungal susceptibility of Candida albicans to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method.
Results: Among 258 women tested, 100 (39%) were positive for Candida species. C. albicans, C. glabrata and C. krusei were isolated from 42, 41 and 17% of the women, respectively. C. albicans was significantly associated only with gestational diabetes while C. krusei or C. glabrata had significant positive associations with other gestational complications. The antifungal susceptibility tests of C. albicans isolates revealed 97.5, 90, 87.5 and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively.
Conclusion: The current study revealed high incidence of both C. albicans and non-C. albicans Candida strains causing vulvovaginitis among pregnant women in Beirut, Lebanon. Candida screening as antenatal follow up is advised to minimize the risk of adverse neonatal outcome or gestational complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958632 | PMC |
| http://dx.doi.org/10.1186/s12879-019-4736-2 | DOI Listing |
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