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Inhibition of β-amyloid Aggregation of Ugni molinae Extracts. | LitMetric

Inhibition of β-amyloid Aggregation of Ugni molinae Extracts.

Curr Pharm Des

Laboratorio de Productos Naturales, Departamento de Quimica Farmacologica y Toxicologica, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile. Sergio Livingston 1007, Santiago 8380492, Chile.

Published: November 2020

AI Article Synopsis

Article Abstract

The β-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the inhibition of β-amyloid aggregation of ethyl acetate and ethanolic extracts obtained from Ugni molinae leaves on neurotoxic actions of β-amyloid aggregates. Chemical analyses were carried out with the extracts in order to determine their phenolic profile and its quantification. Both extracts showed a tendency to reduce neuronal deaths caused by β-amyloid. This tendency was inversely proportional to the evaluated concentrations. Moreover, the effect of EAE and ETE on β-amyloid aggregation was studied by fluorimetric T Thioflavin assay and transmission electronic microscopy (TEM); the extracts showed a modulation in the aggregation process. Partly, it is believed that these effects can be attributed to the polyphenolic compounds present in the extracts.

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Source
http://dx.doi.org/10.2174/1381612826666200113160840DOI Listing

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