In this study, a highly selective fluorescent sensor (E)-2-((2-(benzo[d]thiazol-2-yl)quinolin-8-yl)oxy)-N'-((7-(diethylamino)-2-oxo-2H-chromen-3-yl)methylene)acetohydrazide (TQC) was synthesized from 2-methylquinolin-8-ol and 4-(diethylamino)-2-hydroxybenzaldehyde and its structure was characterized by H NMR, C NMR, ESI-HR-MS and density functional theory (DFT) calculation. Sensor TQC showed an obvious "on-off-on" fluorescence response to Cu and PPi in a DMSO/HEPES (3:2 v/v, pH = 7.4) buffer system. The detection limits of sensor TQC were 0.06 μM to Cu and 0.01 μM to PPi. In addition, sensor TQC showed a 1:1 binding stoichiometry to Cu and TQC-Cu complex showed a 2:1 binding stoichiometry to PPi. The optimum pH range of sensor TQC and TQC-Cu was 3-8. Further studies demonstrated that sensor TQC could be made into test paper strips for the qualitative of Cu and PPi and showed sequentially "on-off-on" fluorescent bio-imaging of Cu and PPi in HeLa cells.
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