AI Article Synopsis
- A new alkaloid called (±)-preisomide was discovered, along with five known polyketides, from the endophytic fungus Preussia isomera found in Panax notoginseng using the OSMAC strategy.
- The structure of the new compound was confirmed through various spectroscopic techniques and literature comparison, highlighting its unique tetrahydro-2H-1,2-oxazin ring.
- Compound 6 showed significant antibacterial properties against multidrug-resistant bacteria, specifically with an MIC of 25 μg/mL, and moderate antifungal activity against Gibberella saubinetii with an MIC of 50 μg/mL.
Article Abstract
A new alkaloid, named (±)-preisomide (1), together with five known polyketides (2-6), were isolated from an endophytic fungus Preussia isomera in Panax notoginseng by using one strain-many compounds (OSMAC) strategy. Their structures were identified by extensive spectroscopic experiments and comparison with literature data. Structurally, compound 1 possessed a rare naturally occurring tetrahydro-2H-1,2-oxazin ring. Compound 6 displayed significant antibacterial activity against multidrug-resistant Enterococcus faecium, methicinllin-resistant Staphylococcus aureus and multidrug-resistant Enterococcus faecalis with an MIC value of 25 μg/mL, as well as moderate antifungal activity against Gibberella saubinetii with an MIC value of 50 μg/mL.
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| http://dx.doi.org/10.1016/j.fitote.2020.104475 | DOI Listing |
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