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Identification of U-shaped curve relation between proneurotensin and risk of coronary artery disease (CAD) in patients with premature CAD. | LitMetric

AI Article Synopsis

  • Neurotensin (NT) is a gut hormone linked to cardiovascular health, and this study investigates serum levels of its precursor, proneurotensin (pro-NT), in patients with premature cardiovascular artery disease (PCAD).
  • The research involved 490 subjects, revealing that pro-NT levels are significantly higher in PCAD patients compared to controls, particularly in those with a body mass index (BMI) under 25 kg/m².
  • A U-shaped relationship was found between pro-NT levels and PCAD risk, indicating individuals with both low and high pro-NT levels have an increased risk of developing PCAD compared to those with median levels.

Article Abstract

Background And Aims: Neurotensin (NT) is a gut hormone with broad effects on the cardiovascular system. Recent data suggested that circulating proneurotensin (pro-NT)-the stable precursor fragment of NT-could independently predict cardiovascular artery disease (CAD) development. However, serum pro-NT levels in patients with premature cardiovascular artery disease (PCAD) are still unknown. This study aims to determine serum pro-NT levels in patients with PCAD and investigate its relationship with PCAD risk.

Methods And Results: A total of 490 subjects, including 364 with PCAD and 126 without PCAD (NPCAD), and 182 controls were enrolled in the study. Data of baseline clinical parameters and biochemical variables were collected. Serum pro-NT levels were measured by ELISA. Serum pro-NT levels were higher in patients with PCAD than in controls (59.42 ± 66.66 vs. 38.07 ± 48.48 pg/mL, P < 0.05), especially in patients with BMI<25 kg/m. Serum pro-NT levels were independently related to PCAD (β = 0.349, P < 0.001), and the association revealed a U-shaped curve characteristic between pro-NT tertiles and CAD risk in patients with premature CAD and controls. Subjects with low and high tertiles of pro-NT levels had 1.79-fold and 2.23-fold higher risks of PCAD, respectively, than subjects with median pro-NT levels (P < 0.05). After adjusting for age, gender, and BMI in Model 1 and other confounders in Model 2 and Model 3, the U-shaped relationship remained significant.

Conclusion: Serum pro-NT levels were significantly increased in patients with PCAD. The association between pro-NT levels and PCAD risk presents a U-shaped curve characteristic, which demonstrated that subjects with lower and higher pro-NT levels both were more likely to have PCAD.

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Source
http://dx.doi.org/10.1016/j.numecd.2019.10.009DOI Listing

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