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Diagnosis and Management of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome in Resource-Constrained Settings: A Case Report and an Adapted Case Definition.
Trop Med Infect Dis
December 2024
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kaposi sarcoma-associated herpes virus (KSHV), also known as human herpes virus 8 (HHV-8), is the primary etiologic cause of Kaposi sarcoma (KS) and KSHV Inflammatory Cytokine Syndrome (KICS). Patients with KICS demonstrate symptoms of systemic inflammation, high KSHV viral load, elevation of inflammatory markers, and increased mortality. Management requires rapid diagnosis, treatment of underlying HIV, direct treatment of KS, and addressing the hyperimmune response.
View Article and Find Full Text PDFThe art of dermatopathology.
Clin Dermatol
December 2024
Department of Dermatology, Yale School of Medicine, New Haven, CT; Department of Pathology, Yale School of Medicine, New Haven, CT.
Dermatopathology, like dermatology, has evolved in many directions; yet, both fields remain true to visual morphology-based diagnosis. Dr. Irwin Braverman is a role model for the intersection of these two visual fields.
View Article and Find Full Text PDFBedside teaching - insights into the medical student experience and likely impact on future role as clinical teacher.
BMC Med Educ
December 2024
Medicine for University of Galway, Mayo Medical Academy, Castlebar, Co. Mayo, Ireland.
Background: Medical students and doctors are rarely taught how to be educators, but are expected to perform the role of clinical teacher once qualified (Kloek AT, Van Zijl ACM, ten Cate OTJ, Perspect Med Educ. 5:325-331, 2016). Qureshi (Perspect Med Edu 3:69-72, 2014) suggests that development of teaching skills should be incorporated into the undergraduate medical curriculum, while Charnell et al.
View Article and Find Full Text PDFMulticellular 3D models to study myocardial ischemia-reperfusion injury.
Front Cell Dev Biol
November 2024
Department of Experimental Vascular Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands.
Coronary heart disease is a major global health threat, with acute myocardial ischemia-reperfusion injury (IRI) being a major contributor to myocardial damage following an ischemic event. IRI occurs when blood flow to ischemic tissues is restored and exacerbates the cellular damage caused by ischemia/hypoxia. Although animal studies investigating IRI have provided valuable insights, their translation into clinical outcomes has been limited, and translation into medical practice remains cumbersome.
View Article and Find Full Text PDFUnraveling the Immune Web: Advances in SMI Capsular Fibrosis from Molecular Insights to Preclinical Breakthroughs.
Biomolecules
November 2024
Department of Plastic, Reconstructive and Aesthetic Surgery, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Breast implant surgery has evolved significantly, yet challenges such as capsular contracture remain a persistent concern. This review presents an in-depth analysis of recent advancements in understanding the immune mechanisms and clinical implications associated with silicone mammary implants (SMIs). The article systematically examines the complex interplay between immune responses and capsular fibrosis, emphasizing the pathophysiological mechanisms of inflammation in the etiology of this fibrotic response.
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