AI Article Synopsis
- Recent studies have linked mercury exposure to fish, milk, and hair in the Amazon, but few have focused on identifying specific biomarkers for this exposure.
- The research analyzed muscle tissues of two fish species commonly consumed by the local population to identify potential biomarkers.
- Four protein SPOTS associated with mercury were found, including parvalbumin and ubiquitin-40S ribosomal protein S27a, indicating these metalloproteins could serve as effective biomarkers for mercury exposure.
Article Abstract
Recent studies have demonstrated the association of mercury (Hg) with some fish proteins, milk, and hair from individuals exposed to the element in the Amazon. However, few studies involve identifying biomarkers of mercury exposure. Therefore, the present study aimed to identify potential biomarkers of Hg exposure in fish. For this, the muscular tissues of two species of fish (Prochilodus lineatus and Mylossoma duriventre) that feed the Amazonian human population were analyzed. Through the analyses obtained by graphite furnace atomic absorption spectrometry (GFAAS), it was possible to identify four protein SPOTS where mercury was present. These SPOTS, identified by mass spectrometry (ESI-MS/MS), included parvalbumin and ubiquitin-40S ribosomal protein S27a, and these being metalloproteins with biomarker characteristics. In addition, the results show the intense Hg/protein ratio observed in the two proteins, which makes metalloproteins strong candidates for biomarkers of mercury exposure. Graphical Abstract.
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