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Association between infection and health Outcomes: an umbrella review of systematic reviews and meta-analyses. | LitMetric

AI Article Synopsis

  • - The study conducted an umbrella review of systematic reviews and meta-analyses to evaluate the connections between infections and various health outcomes, examining data from multiple academic databases up until February 2019.
  • - Out of 60 articles, 88 unique health outcomes were analyzed, revealing that 74 outcomes showed significance, with 61 linked to harmful effects and only 13 to beneficial effects, while a high percentage exhibited significant variability and low methodological quality.
  • - The findings indicated that infections may increase the risk of several diseases, including gastric cancer and gestational diabetes, but could potentially decrease the risk of irritable bowel syndrome, highlighting the need for more reliable evidence on these associations.

Article Abstract

Objective: Systematic reviews and meta-analyses have revealed the associations between infection and various health outcomes. We aimed to evaluate the strength and breadth of evidence on the associations.

Design: Umbrella review of systematic reviews and meta-analyses.

Setting: No settings.

Participants: No patients involved.

Data Sources: Embase, PubMed, Web of Science, Cochrane Library Databases, CNKI, VIP database and Wangfang database from inception to February 1, 2019.

Outcomes Measures: Diverse diseases (such as cancer and ischaemic heart disease).

Results: Sixty articles reporting 88 unique outcomes met the eligible criteria. 74 unique outcomes had nominal significance (p<0.05). Of the outcomes with significance, 61 had harmful associations and 13 had beneficial associations. Furthermore, 73% (64) of the outcomes exhibited significant heterogeneity . Of the these meta-analyses, 32 had moderate to high heterogeneity (I=50%-75%) and 24 had high heterogeneity (I>75%). Moreover, 20% exhibited publication bias (p<0.1). In addition, 97% of the methodological qualities were rated 'critically low'. 36% of the evidence qualities of outcomes were rated 'low', 56% of the evidence qualities were rated 'very low' and 8% of the evidence qualities were rated 'moderate'. infection may be associated with an increased risk of five diseases and a decreased risk of irritable bowel syndrome.

Conclusion: Although 60 meta-analyses explored 88 unique outcomes, moderate quality evidence only existed for six outcomes with statistical significance. infection may be associated with a decreased risk of irritable bowel syndrome and an increased risk of hypertriglyceridemia, chronic cholecystitis and cholelithiasis, gestational diabetes mellitus, gastric cancer and systemic sclerosis.

Trial Registration: CRD42019124680.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955574PMC
http://dx.doi.org/10.1136/bmjopen-2019-031951DOI Listing

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