A receive-only surface coil array for 3 Tesla integrating a high-permittivity material (HPM) with a relative permittivity of 660 was designed and constructed and subsequently its performance was evaluated and compared in terms of transmit field efficiency and specific absorption ratio (SAR) during transmission, and signal-to-noise ratio during reception, with a conventional identically-sized surface coil array. Finite-difference time-domain simulations, bench measurements and in-vivo neck imaging on three healthy volunteers were performed using a three-element surface coil array with integrated HPMs placed around the larynx. Simulation results show an increase in local transmit efficiency of the body coil of ~10-15% arising from the presence of the HPM. The receiver efficiency also increased by approximately 15% close to the surface. Phantom experiments confirmed these results. In-vivo scans using identical transmit power resulted in SNR gains throughout the laryngeal area when compared with the conventional surface coil array. In particular specifically around the carotid arteries an average SNR gain of 52% was measured averaged over the three subjects, while in the spine an average of 20% SNR gain was obtained.
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http://dx.doi.org/10.1016/j.jmr.2019.106681 | DOI Listing |
Pharmaceutics
December 2024
Department of Applied Chemistry, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
: This study aimed to design and evaluate Chol-PEG micelles and Chol-PEG vesicles as drug delivery system (DDS) carriers and inhibitors of amyloid-β (Aβ) aggregation, a key factor in Alzheimer's disease (AD). : The physical properties of Chol-PEG assemblies were characterized using dynamic light scattering (DLS), electrophoretic light scattering (ELS), and transmission electron microscopy (TEM). Inhibitory effects on Aβ aggregation were assessed via thioflavin T (ThT) assay, circular dichroism (CD) spectroscopy, and native polyacrylamide gel electrophoresis (native-PAGE).
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January 2025
College of Tourism and Culinary Institute, Yangzhou University, Yangzhou 225127, China.
This study examined the effects of varying microwave treatment durations (0-120 s) on the structural and functional properties of glycosylated soybean 7S protein. The results indicated that microwaving for 60 s significantly altered the structure of 7S, resulting in a more ordered protein configuration. The treated protein exhibited the largest particle size (152.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Department of Information Engineering, Electronics and Telecommunications (DIET) , University of Rome La Sapienza, Via Eudossiana 18, Rome, 00184, ITALY.
Objective: This study introduces the effective electric field (Eeff) as a novel observable for transcranial magnetic stimulation (TMS) numerical dosimetry. Eeff represents the electric field component aligned with the local orientation of cortical and white matter neuronal elements. To assess the utility of Eeff as a predictive measure for TMS outcomes, we evaluated its correlation with TMS induced muscle responses and compared it against conventional observables, including the electric (E-)field magnitude, and its components normal and tangential to the cortical surface.
View Article and Find Full Text PDFFood Res Int
February 2025
College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225127, China. Electronic address:
Effects of enzymolysis by seven proteases (Alcalase, Bromelain, Flavourzyme, Papain, Pepsin, Protamex, and Trypsin) with distinct cleavage specificities on the emulsification performance of hempseed protein (HPI) and its correlation with the structural and interfacial characteristics were explored in this study. Upon enzymolysis, a remarkable decrease in α-helix and β-turn was observed in resultant hydrolysates (HPH), accompanied by a rise in β-sheet and random coil, notably by Alcalase, Bromelain, Papain, and Trypsin. Overall, proteolysis led to noticeable reductions in surface hydrophobicity and total sulfhydryls as well as a redshift in intrinsic fluorescence, with Papain showing the most pronounced effects, possibly due to its higher hydrolysis degree (4.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
School of Food Science and Technology, Kyungpook National University, Daegu 702-701, Republic of Korea; Research Institute of Tailored Food Technology, Kyungpook National University, Daegu 41566, Republic of Korea. Electronic address:
Zophobas morio protein (ZMP) is a promising protein resource with notable biological properties, and its hydrolysis could unlock enhanced bioactivities. This study investigated ultrasound-assisted enzymatic hydrolysis (UAEH) of ZMP using different enzymes (Alcalase, Neutrase, and Protamex) to determine its effect on the degree of hydrolysis (DH) compared to enzymatic hydrolysis (EH). UAEH showed greater hydrolysis efficiency than EH, with Alcalase exhibiting the highest DH.
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