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Targeted donor complement blockade after brain death prevents delayed graft function in a nonhuman primate model of kidney transplantation. | LitMetric

AI Article Synopsis

  • *In a study using nonhuman primates, complement-blockade in brain-dead kidney donors significantly reduced inflammation and DGF in recipients, compared to control groups.
  • *Results showed that kidney transplants from donors treated with complement inhibitors had no instances of DGF and better overall function compared to non-treated donors and controls.

Article Abstract

Delayed graft function (DGF) in renal transplant is associated with reduced graft survival and increased immunogenicity. The complement-driven inflammatory response after brain death (BD) and posttransplant reperfusion injury play significant roles in the pathogenesis of DGF. In a nonhuman primate model, we tested complement-blockade in BD donors to prevent DGF and improve graft survival. BD donors were maintained for 20 hours; kidneys were procured and stored at 4°C for 43-48 hours prior to implantation into ABO-compatible, nonsensitized, MHC-mismatched recipients. Animals were divided into 3 donor-treatment groups: G1 - vehicle, G2 - rhC1INH+heparin, and G3 - heparin. G2 donors showed significant reduction in classical complement pathway activation and decreased levels of tumor necrosis factor α and monocyte chemoattractant protein 1. DGF was diagnosed in 4/6 (67%) G1 recipients, 3/3 (100%) G3 recipients, and 0/6 (0%) G2 recipients (P = .008). In addition, G2 recipients showed superior renal function, reduced sC5b-9, and reduced urinary neutrophil gelatinase-associated lipocalin in the first week posttransplant. We observed no differences in incidence or severity of graft rejection between groups. Collectively, the data indicate that donor-management targeting complement activation prevents the development of DGF. Our results suggest a pivotal role for complement activation in BD-induced renal injury and postulate complement blockade as a promising strategy for the prevention of DGF after transplantation.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261643PMC
http://dx.doi.org/10.1111/ajt.15777DOI Listing

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