To assess outcomes and treatment related toxicity following intensity-modulated radiotherapy (IMRT) and a Carbon Ion Radiotherapy (CIRT) boost for salivary duct carcinoma (SDC). Twenty-eight consecutive patients with SDC who underwent a postoperative (82%) or definitive (18%) radiation therapy between 2010 and 2017 were assessed in this retrospective single-center analysis. CIRT boost was delivered with median 18 Gy(RBE) in 6 daily fractions, followed by an TomoTherapy-based IMRT (median 54 Gy in 27 daily fractions). Treatment-related acute toxicity was assessed according to CTCAE Version 4. Tumors were most commonly located in the major salivary glands ( = 25; 89%); 23 patients (82%) received previous surgery (R0: 30%; R1: 57%; R2: 4%; RX: 19%). Median follow-up was 30 months. Four patients (14%) experienced a local relapse and 3 (11%) developed locoregional recurrence. The two-year local control (LC) and locoregional control (LRC) was 96 and 93%, respectively. Median disease-free survival (DFS) was 27 months, metastasis-free survival (MFS) was 69 months, and overall survival (OS) was 93 months. Acute grade 3 toxicity occurred in 11 patients (mucositis, dermatitis, xerostomia; = 2 each (7%) were the most common) and 2 osteonecroses of the mandibular (grade 3) occurred. No patients experienced grade ≥4 toxicities. Multimodal therapy approaches with surgery followed by IMRT and CIRT boost for SDC leads to good local and locoregional disease control. However, the frequent occurrence of distant metastases limits the prognosis and requires optimization of adjuvant systemic therapies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932999 | PMC |
| http://dx.doi.org/10.3389/fonc.2019.01420 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic models for progression-free survival in atypical meningioma: Comparison of machine learning-based approach and the COX model in an Asian multicenter study.
Radiother Oncol
December 2024
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, South Korea; Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
Background And Purpose: Atypical meningiomas are prevalent intracranial tumors with varied prognoses and recurrence rates. The role of adjuvant radiotherapy (ART) in atypical meningiomas remains debated. This study aimed to develop and validate a prognostic model incorporating machine learning techniques and clinical factors to predict progression-free survival (PFS) in patients with atypical meningiomas and assess the impact of ART.
View Article and Find Full Text PDFClinical Outcomes of Carbon Ion Radiation Therapy for Malignant Peripheral Nerve Sheath Tumors.
Adv Radiat Oncol
November 2024
Radiation Oncology Unit, Clinical Department, CNAO National Center for Oncological Hadrontherapy, Pavia, Italy.
Article Synopsis
- The study aimed to assess the effectiveness and side effects of high-dose carbon ion radiation therapy (CIRT) in treating patients with malignant peripheral nerve sheath tumors (MPNSTs), analyzing data from 23 patients treated between 2013 and 2020.
- Results showed promising overall survival rates of approximately 82% at 1 year and 61.5% at 2 years, alongside local relapse-free survival rates of 65% and 48.8% at the same intervals, with no treatment-related deaths reported.
- While some patients experienced acute (43.5%) and late (34.8%) toxicities mostly classified as grade 2 or higher, there were no severe toxicities (grade 4)
Craniospinal irradiation using pencil beam Scanning: The PSI experience.
Phys Med
November 2024
Center for Proton Therapy, Paul Scherrer Institute, ETH Domain, CH-5232 Villigen, Switzerland; Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Radiation Oncology, University Hospital of Zürich, Zürich, Switzerland.
Article Synopsis
- The study evaluated craniospinal irradiation (CSI) treatments using protons at the Paul Scherrer Institute, focusing on local recurrences and late toxicity outcomes for 71 patients, mostly children and young adults with tumors like medulloblastoma and ependymoma.
- Data from patients treated in both prone and supine positions were analyzed, revealing that supine positioning led to lower systematic and random errors in treatment setup, resulting in more accurate dosing.
- The research concluded that local failures in treatment were not linked to inaccuracies in radiation dosing, and there was no observed correlation between treatment-related toxicities and increased radiation effects.
Proton beam therapy in a patient with secondary glioblastoma (32 years after postoperative irradiation of medulloblastoma): case report and literature review.
Radiat Oncol
October 2024
Department of Pediatric Radiation Therapy Center/Pediatric Proton Beam Therapy Center, Hebei Yizhou Cancer Hospital, Zhuozhou, 072750, China.
Article Synopsis
- This report highlights the case of a male patient who developed a second glioblastoma 32 years after being treated for medulloblastoma, emphasizing the treatment process and relevant literature.
- The patient underwent successful surgery and was treated with proton beam therapy and Temozolomide, resulting in a complete response after his radiation-induced glioblastoma was diagnosed.
- The discussion includes the importance of molecular profiling in managing second primary tumors like RIGB and underscores the advantages of proton beam therapy for protecting healthy tissue during high-dose treatment.
Balancing benefits and limitations of linear energy transfer optimization in carbon ion radiotherapy for large sacral chordomas.
Phys Imaging Radiat Oncol
July 2024
Department of Electronics, Information and Bioengineering, Politecnico di Milano, Via G.Ponzio 34/5, 20133 Milan, Italy.
Background And Purpose: A low linear energy transfer (LET) in the target can reduce the effectiveness of carbon ion radiotherapy (CIRT). This study aimed at exploring benefits and limitations of LET optimization for large sacral chordomas (SC) undergoing CIRT.
Materials And Methods: Seventeen cases were used to tune LET-based optimization, and seven to independently test interfraction plan robustness.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!