AI Article Synopsis
- DGCR5 is a long non-coding RNA that is found to be down-regulated in prostate cancer tissues compared to adjacent healthy tissues, while TGF-β1 is up-regulated in the same tumor tissues.
- Low levels of DGCR5 are linked to poor survival outcomes, indicating its potential role as a prognostic marker in prostate cancer.
- The study suggests that DGCR5 reduces the stemness of prostate cancer cells by down-regulating TGF-β1, while TGF-β1 seems to counteract the beneficial effects of DGCR5.
Article Abstract
Background: Long non-coding RNA (lncRNA) DiGeorge syndrome critical region gene 5 (DGCR5) plays different roles in different types of human cancer, but its role in prostate cancer (PC) has not been reported.
Methods: DGCR5 and TGF-β1 expression in paired tumor and adjacent healthy tissues from 64 PC patients was analyzed by performing RT-qPCR. A 5-year follow-up study was performed to analyze the prognostic value of DGCR5 for PC. The interaction between DGCR5 and TGF-β1 was analyzed by overexpression experiments. Cell stemness was analyzed by cell stemness assay.
Results: In our study, we found that DGCR5 was down-regulated in tumor tissues than in adjacent healthy tissues of PC patients, but TGF-β1 was up-regulated in the tumor tissues. DGCR5 expression was not affected by clinical stages, but low DGCR5 level in the tumor was correlated with poor survival. DGCR5 and TGF-β1 were inversely correlated in tumor tissues but not in adjacent healthy tissues. DGCR5 over-expression resulted in down-regulation of TGF-β1, while TGF-β1 treatment did not significantly affect DGCR5 expression. DGCR5 over-expression led to decreased stemness of PC cells, but TGF-β1 treatment played a reverse role and attenuated the effects of DGCR5 over-expression. DGCR5 may decrease the stemness of PC cells by down-regulating TGF-β1.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939399 | PMC |
| http://dx.doi.org/10.2147/CMAR.S231112 | DOI Listing |
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